Abstract:
Scutellarin, one of natural flavonoids from Scutellaria barbata D. Don and Erigeron breviscapus (vant) Hand.-Mazz. Modern pharmacological studies have shown that scutellarin has a good anti-tumor effect. According to the literature review at home and abroad, scutellarin can inhibit the growth and metastasis of tumor cells, block the cell cycle at various stages, induce apoptosis and autophagy, interfere with tumor metabolism, reverse drug resistance of tumor cells and enhance the sensitivity of chemotherapy drugs. In this paper, the anti-tumor mechanism of scutellarin was reviewed, and the shortcomings of current studies and future research directions were analyzed, so as to provide a basis for further exploration of the anti-tumor potential of scutellarin and its further development and utilization.
摘要:
Scutellarin,一种来自半枝莲D.Don和灯盏细辛(vant)手的天然黄酮类化合物。-爵士.现代药理研究表明,灯盏乙素具有良好的抗肿瘤作用。根据国内外文献综述,灯盏乙素可抑制肿瘤细胞的生长和转移,在不同阶段阻断细胞周期,诱导细胞凋亡和自噬,干扰肿瘤代谢,逆转肿瘤细胞的耐药性,增强化疗药物的敏感性。在本文中,综述了灯盏乙素的抗肿瘤作用机制,分析了当前研究的不足和未来的研究方向,从而为进一步探索灯盏乙素的抗肿瘤潜力及其进一步开发利用提供依据。