METHODS: The medical records of 256 CRS patients were retrospectively analyzed. All were divided into nonallergic, house dust mite (HDM)-allergic, pollen-allergic, and double allergic groups via specific immunoglobulin E (IgE) testing. Clinical characteristics, computed tomography (CT) scores, olfactory functions, and demographic data were compared. Correlation analysis was performed to explore the relationships between the extent of allergen sensitization and CRS severity. Binary logistic regression analysis was used to identify risk factors for hyposmia and anosmia.
RESULTS: The allergic group exhibited higher total CT scores than the nonallergic group (P = 0.001). Sensitivity to HDM or pollen allergens alone was not significantly associated with increased CRS severity. No significant differences were observed between the effects of HDM and pollen allergens on CRS severity. However, the double allergic group exhibited significantly higher CT scores (P < 0.001, < 0.001, and 0.003) than the other groups. Although the prevalence rates of anosmia and hyposmia were notably higher in the double allergic group, the difference was not statistically significant. The maximum specific IgE levels to HDM and pollen allergens positively correlated with the CT scores (P = 0.001 and 0.001, respectively).
CONCLUSIONS: Allergen sensitization, particularly to multiple common allergens, contributed to CRS severity. CRS patients sensitized to both HDM and pollen allergens tended to experience the diminished olfactory function. These findings underscore the importance of considering the allergen sensitization pattern when assessing CRS severity and its potential progression.
方法:对256例CRS患者的病历资料进行回顾性分析。全部分为非过敏性,室内尘螨(HDM)-过敏,花粉过敏,和双重过敏组通过特异性免疫球蛋白E(IgE)测试。临床特征,计算机断层扫描(CT)评分,嗅觉功能,和人口统计数据进行了比较。采用相关性分析探讨变应原致敏程度与CRS严重程度的关系。采用二元logistic回归分析确定失语和失语症的危险因素。
结果:过敏组的CT总分高于非过敏组(P=0.001)。仅对HDM或花粉过敏原的敏感性与CRS严重程度的增加没有显着相关。在HDM和花粉过敏原对CRS严重程度的影响之间没有观察到显着差异。然而,双重过敏组的CT评分明显高于其他组(P<0.001,<0.001和0.003)。尽管双过敏组的嗅觉缺失和嗅觉减退的患病率明显较高,差异无统计学意义。HDM和花粉过敏原的最大特异性IgE水平与CT评分呈正相关(分别为P=0.001和0.001)。
结论:过敏原致敏,特别是多种常见的过敏原,导致CRS严重程度。对HDM和花粉过敏原均敏感的CRS患者倾向于经历嗅觉功能减弱。这些发现强调了在评估CRS严重程度及其潜在进展时考虑过敏原致敏模式的重要性。