PDF(Pubmed)
Abstract：
BACKGROUND: Liver cancer (LC) is a prevalent malignancy and a leading cause of cancer-related mortality worldwide. Extensive research has been conducted to enhance patient outcomes and develop effective prevention strategies, ranging from molecular mechanisms to clinical interventions. Single-cell sequencing, as a novel bioanalysis technology, has significantly contributed to the understanding of the global cognition and dynamic changes in liver cancer. However, there is a lack of bibliometric analysis in this specific research area. Therefore, the objective of this study is to provide a comprehensive overview of the knowledge structure and research hotspots in the field of single-cell sequencing in liver cancer research through the use of bibliometrics.
METHODS: Publications related to the application of single-cell sequencing technology to liver cancer research as of December 31, 2023, were searched on the web of science core collection (WoSCC) database. VOSviewers, CiteSpace, and R package \"bibliometrix\" were used to conduct this bibliometric analysis.
RESULTS: A total of 331 publications from 34 countries, primarily led by China and the United States, were included in this study. The research focuses on the application of single cell sequencing technology to liver cancer, and the number of related publications has been increasing year by year. The main research institutions involved in this field are Fudan University, Sun Yat-Sen University, and the Chinese Academy of Sciences. Frontiers in Immunology and Nature Communications is the most popular journal in this field, while Cell is the most frequently co-cited journal. These publications are authored by 2799 individuals, with Fan Jia and Zhou Jian having the most published papers, and Llovet Jm being the most frequently co-cited author. The use of single cell sequencing to explore the immune microenvironment of liver cancer, as well as its implications in immunotherapy and chemotherapy, remains the central focus of this field. The emerging research hotspots are characterized by keywords such as \'Gene-Expression\', \'Prognosis\', \'Tumor Heterogeneity\', \'Immunoregulation\', and \'Tumor Immune Microenvironment\'.
CONCLUSIONS: This is the first bibliometric study that comprehensively summarizes the research trends and developments on the application of single cell sequencing in liver cancer. The study identifies recent research frontiers and hot directions, providing a valuable reference for researchers exploring the landscape of liver cancer, understanding the composition of the immune microenvironment, and utilizing single-cell sequencing technology to guide and enhance the prognosis of liver cancer patients.
METHODS: Publications related to the application of single-cell sequencing technology to liver cancer research as of December 31, 2023, were searched on the web of science core collection (WoSCC) database. VOSviewers, CiteSpace, and R package \"bibliometrix\" were used to conduct this bibliometric analysis.
RESULTS: A total of 331 publications from 34 countries, primarily led by China and the United States, were included in this study. The research focuses on the application of single cell sequencing technology to liver cancer, and the number of related publications has been increasing year by year. The main research institutions involved in this field are Fudan University, Sun Yat-Sen University, and the Chinese Academy of Sciences. Frontiers in Immunology and Nature Communications is the most popular journal in this field, while Cell is the most frequently co-cited journal. These publications are authored by 2799 individuals, with Fan Jia and Zhou Jian having the most published papers, and Llovet Jm being the most frequently co-cited author. The use of single cell sequencing to explore the immune microenvironment of liver cancer, as well as its implications in immunotherapy and chemotherapy, remains the central focus of this field. The emerging research hotspots are characterized by keywords such as \'Gene-Expression\', \'Prognosis\', \'Tumor Heterogeneity\', \'Immunoregulation\', and \'Tumor Immune Microenvironment\'.
CONCLUSIONS: This is the first bibliometric study that comprehensively summarizes the research trends and developments on the application of single cell sequencing in liver cancer. The study identifies recent research frontiers and hot directions, providing a valuable reference for researchers exploring the landscape of liver cancer, understanding the composition of the immune microenvironment, and utilizing single-cell sequencing technology to guide and enhance the prognosis of liver cancer patients.
摘要：
背景：肝癌（LC）是一种普遍的恶性肿瘤，是全球癌症相关死亡率的主要原因。进行了广泛的研究，以提高患者的治疗效果并制定有效的预防策略，从分子机制到临床干预。单细胞测序，作为一种新颖的生物分析技术，显著促进了对肝癌整体认知和动态变化的理解。然而,在这一具体研究领域缺乏文献计量学分析。因此,本研究的目的是通过文献计量学的方法，对肝癌研究中单细胞测序领域的知识结构和研究热点进行全面概述。
方法：在科学核心收藏（WoSCC）数据库的网络上搜索了截至2023年12月31日与单细胞测序技术在肝癌研究中的应用有关的出版物。听者,CiteSpace,和R包“bibliometrix”用于进行此文献计量分析。
结果：共有来自34个国家的331种出版物，主要由中国和美国领导，包括在这项研究中。研究重点是单细胞测序技术在肝癌中的应用,相关出版物的数量逐年增加。参与这一领域的主要研究机构是复旦大学,中山大学,和中国科学院。免疫学和自然通讯前沿是该领域最受欢迎的期刊，而Cell是最常被共同引用的期刊。这些出版物由2799人撰写，范佳和周健发表的论文最多，LlovetJm是最常被共同引用的作者。利用单细胞测序探索肝癌的免疫微环境,以及它在免疫疗法和化疗中的意义，仍然是这个领域的焦点。新兴的研究热点以“基因表达”等关键词为特征，\'预后\',\'肿瘤异质性\'，\'免疫调节\',和“肿瘤免疫微环境”。
结论：这是第一个文献计量学研究，全面总结了单细胞测序在肝癌中应用的研究趋势和进展。这项研究确定了最近的研究前沿和热点方向，为研究人员探索肝癌的景观提供了有价值的参考，了解免疫微环境的组成，利用单细胞测序技术指导和提高肝癌患者的预后。
方法：在科学核心收藏（WoSCC）数据库的网络上搜索了截至2023年12月31日与单细胞测序技术在肝癌研究中的应用有关的出版物。听者,CiteSpace,和R包“bibliometrix”用于进行此文献计量分析。
结果：共有来自34个国家的331种出版物，主要由中国和美国领导，包括在这项研究中。研究重点是单细胞测序技术在肝癌中的应用,相关出版物的数量逐年增加。参与这一领域的主要研究机构是复旦大学,中山大学,和中国科学院。免疫学和自然通讯前沿是该领域最受欢迎的期刊，而Cell是最常被共同引用的期刊。这些出版物由2799人撰写，范佳和周健发表的论文最多，LlovetJm是最常被共同引用的作者。利用单细胞测序探索肝癌的免疫微环境,以及它在免疫疗法和化疗中的意义，仍然是这个领域的焦点。新兴的研究热点以“基因表达”等关键词为特征，\'预后\',\'肿瘤异质性\'，\'免疫调节\',和“肿瘤免疫微环境”。
结论：这是第一个文献计量学研究，全面总结了单细胞测序在肝癌中应用的研究趋势和进展。这项研究确定了最近的研究前沿和热点方向，为研究人员探索肝癌的景观提供了有价值的参考，了解免疫微环境的组成，利用单细胞测序技术指导和提高肝癌患者的预后。
