Abstract：
The proposed glucosylamine oxidation pathway (GOP) is a two-step, intraerythrocyte, thermodynamically favorable nonenzymatic reaction that first binds glucose to the N-terminal valine of beta globin (βVal1) to form a closed-chain glucosylamine that can spontaneously reduce oxidized vitamin C to its antioxidant form. This review summarizes analytical, biochemical and clinical research supporting the existence of the GOP and the surprising hypothesis that βVal1 glucosylamine is a reducing agent that works cooperatively with reduced glutathione to dynamically regulate vitamin C recycling during naturally occurring periods of transiently or chronically elevated blood glucose and oxidant production. Rationale for the existence of the GOP is presented from the perspective of the hemoglobin glycation index, a clinically practical biomarker of risk for chronic vascular disease that we propose is mechanistically explained by person-to-person variation in GOP activity.
摘要：
建议的葡萄糖胺氧化途径（GOP）是一个两步，红细胞内,热力学上有利的非酶促反应，该反应首先将葡萄糖与β珠蛋白（βVal1）的N末端缬氨酸结合，形成可以自发地将氧化的维生素C还原为其抗氧化剂形式的闭链葡糖胺。这篇综述总结了分析性的，生化和临床研究支持GOP的存在，以及令人惊讶的假设，即βVal1葡萄糖胺是一种还原剂，可与还原型谷胱甘肽协同作用，在短暂或慢性升高的血糖和氧化剂产生的自然发生时期动态调节维生素C的回收。从血红蛋白糖化指数的角度提出了GOP存在的基本原理，我们提出的慢性血管疾病风险的临床实用生物标志物在机制上通过人与人之间的GOP活性差异来解释.
