Abstract：
Increased cardiometabolic risk is associated with abnormalities in blood biomarkers profile and adiposity measurements. Some substances found in the food matrix and the environment, called endocrine-disrupting chemicals, may impair cardiometabolic health in the early and later stages of life. Bisphenol A (BPA) is a food contaminant that migrates from food contact materials and may act as an endocrine disruptor, negatively affecting human health. The present work aims to longitudinally assess the association between BPA exposure and cardiometabolic outcomes, considering data from Portuguese population-based birth cohort Generation XXI. Blood insulin (0.06stdβ; 95 %CI:0.03,0.09) and insulin resistance (0.05stdβ; 95 %CI:0.02,0.08) presented a significant longitudinal association with BPA daily exposure after adjustment for important variables and energy. The same findings were observed for fat mass (0.03stdβ; 95 %CI 0.01,0.06) and waist circumference (0.06stdβ; 95 %CI:0.04,0.08). For z-BMI, a significant cross-sectional (0.03stdβ; 95 %CI:0.01,0.04) and longitudinal (0.02stdβ; 95 %CI:0.00,0.04) association was found. This was the first study assessing the association between BPA exposure and health outcomes from childhood to adolescence. We found an association between BPA exposure and increased blood insulin level, insulin resistance, fat mass percentage, waist circumference and z-BMI. Our results point to the need to reduce exposure to BPA in the early stages of life.
摘要：
心脏代谢风险增加与血液生物标志物谱和肥胖测量异常相关。在食物基质和环境中发现的一些物质，称为内分泌干扰化学物质，可能在生命的早期和后期损害心脏代谢健康。双酚A（BPA）是一种从食品接触材料中迁移出来的食品污染物，可能是一种内分泌干扰物。对人类健康产生负面影响。本工作旨在纵向评估BPA暴露与心脏代谢结果之间的关系，考虑来自葡萄牙基于人口的出生队列的数据。血液胰岛素（0.06stdβ;95CI：0.03,0.09）和胰岛素抵抗（0.05stdβ;95CI：0.02,0.08）在调整重要变量和能量后与BPA每日暴露呈显着的纵向关联。对于脂肪量(0.03stdβ;95CI0.01,0.06)和腰围(0.06stdβ;95CI:0.04,0.08)也观察到了相同的发现。对于z-BMI，发现显著的横截面(0.03stdβ;95CI:0.01,0.04)和纵向(0.02stdβ;95CI:0.00,0.04)相关.这是第一项评估从儿童到青春期BPA暴露与健康结果之间关联的研究。我们发现BPA暴露与血液胰岛素水平升高之间存在关联，胰岛素抵抗，脂肪质量百分比，腰围和z-BMI。我们的研究结果表明，在生命的早期阶段需要减少对BPA的暴露。
