Abstract：
Recent investigations have demonstrated abnormal expression of non-coding RNAs in pituitary adenomas. Cntribution of many lncRNAs to the pathogenesis of these tumors has not been evaluated yet. HOTTIP, ANRIL, PANDAR, PCGEM1 and HOTAIR are among lncRNAs with established roles in the pathogenesis of human cancers, particularly those originated from endocrine organs. The current study aims at assessment of expression of these lncRNAs in pituitary adenomas in comparison with the adjacent non-cancerous pituitary tissues. HOTAIR expression was absent from the majority of adenoma and non-tumoral samples. Expression of HOTTIP was significantly higher in non-functioning pituitary adenoma (NFPA) samples compared with paired normal samples (expression ratio (95 % CI)= 2.1 (1.13-2.1), P value=0.03). Expression of PANDAR was higher in total adenoma samples compared with paired normal samples (expression ratio (95 % CI)= 1.91 (1.16-3.13), P value=0.02). Expression of ANRIL was higher in NFPA samples compared with paired normal samples (expression ratio (95 % CI)= 1.94 (1.05-3.6), P value=0.048) and in total adenoma samples compared with paired normal samples (expression ratio (95 % CI)= 1.82 (1.11-2.98), P value=0.025). The current study raises the possibility of contribution of lncRNAs in the pathogenesis of at least some subtypes of pituitary adenomas and warrant further functional studies in this field.
摘要：
最近的研究已经证明非编码RNA在垂体腺瘤中的异常表达。尚未评估许多lncRNAs对这些肿瘤发病机理的归因。HOTTIP,ANRIL,PANDAR,PCGEM1和HOTAIR是在人类癌症发病机制中具有既定作用的lncRNAs，特别是那些起源于内分泌器官的。本研究旨在评估这些lncRNAs在垂体腺瘤中与邻近的非癌垂体组织相比的表达。大多数腺瘤和非肿瘤样品中不存在HOTAIR表达。HOTTIP在无功能垂体腺瘤（NFPA）样本中的表达明显高于配对正常样本（表达率（95％CI）=2.1（1.13-2.1），P值=0.03)。与配对正常样本相比，PANDAR在总腺瘤样本中的表达更高（表达率（95％CI）=1.91（1.16-3.13），P值=0.02)。与配对的正常样本相比，NFPA样本中ANRIL的表达更高（表达率（95％CI）=1.94（1.05-3.6），P值=0.048），并且在总腺瘤样本中与配对正常样本相比（表达率（95％CI）=1.82（1.11-2.98），P值=0.025)。目前的研究提出了lncRNAs在垂体腺瘤的至少一些亚型的发病机制中的贡献的可能性，并需要在该领域进行进一步的功能研究。
