Abstract：
UNASSIGNED: Cigarette smoking can lead to a host of adverse health effects such as lung and heart disease. Increased lung cancer risk is associated with inhalation of carcinogens present in a puff of smoke. These carcinogenic compounds deposit in the lung at different sites and trigger a cascade of events leading to adverse outcomes. Understanding the site-specific deposition of various smoke constituents will inform the study of respiratory diseases from cigarette smoking. We previously developed a deposition model for inhalation of aerosol from electronic nicotine delivery systems. In this study, the model was modified to simulate inhalation of cigarette smoke consisting of soluble and insoluble tar, nicotine, and cigarette-specific constituents that are known or possible human carcinogens.
UNASSIGNED: The deposition model was further modified to account for nicotine protonation and other cigarette-specific physics-based mechanisms that affect smoke deposition. Model predictions showed a total respiratory tract uptake in the lung for formaldehyde (99%), nicotine (80%), and benzo[a]pyrene (60%).
UNASSIGNED: The site of deposition and uptake depended primarily on the constituent\'s saturation vapor pressure. High vapor pressure constituents such as formaldehyde were preferentially absorbed in the oral cavity and proximal lung regions, while low vapor pressure constituents such as benzo[a]pyrene were deposited in the deep lung regions. Model predictions of exhaled droplet size, droplet retention, nicotine retention, and uptake of aldehydes compared favorably with experimental data.
UNASSIGNED: The deposition model can be integrated into exposure assessments and other studies that evaluate potential adverse health effects from cigarette smoking.
UNASSIGNED: The deposition model was further modified to account for nicotine protonation and other cigarette-specific physics-based mechanisms that affect smoke deposition. Model predictions showed a total respiratory tract uptake in the lung for formaldehyde (99%), nicotine (80%), and benzo[a]pyrene (60%).
UNASSIGNED: The site of deposition and uptake depended primarily on the constituent\'s saturation vapor pressure. High vapor pressure constituents such as formaldehyde were preferentially absorbed in the oral cavity and proximal lung regions, while low vapor pressure constituents such as benzo[a]pyrene were deposited in the deep lung regions. Model predictions of exhaled droplet size, droplet retention, nicotine retention, and uptake of aldehydes compared favorably with experimental data.
UNASSIGNED: The deposition model can be integrated into exposure assessments and other studies that evaluate potential adverse health effects from cigarette smoking.
摘要：
吸烟会导致许多不良健康影响，如肺部和心脏疾病。肺癌风险增加与吸入烟雾中存在的致癌物质有关。这些致癌化合物沉积在肺中的不同部位并引发一系列导致不良结果的事件。了解各种烟雾成分的特定部位沉积将为研究吸烟引起的呼吸道疾病提供信息。我们先前开发了用于从电子尼古丁递送系统吸入气溶胶的沉积模型。在这项研究中,对该模型进行了修改，以模拟由可溶性和不溶性焦油组成的香烟烟雾的吸入，尼古丁,以及已知或可能的人类致癌物的香烟特有成分。
■进一步修改了沉积模型，以解释尼古丁质子化和其他影响烟雾沉积的基于香烟特定物理的机制。模型预测显示，肺部呼吸道对甲醛的总吸收（99％），尼古丁（80%）和苯并[a]芘(60%)。
■沉积和吸收的位置主要取决于成分的饱和蒸气压。甲醛等高蒸气压成分优先吸收在口腔和近肺区域，而低蒸气压成分如苯并[a]芘沉积在肺深处。呼出液滴大小的模型预测，液滴保留,尼古丁滞留,醛的吸收与实验数据相比较好。
■可以将沉积模型整合到暴露评估和其他评估吸烟对健康的潜在不利影响的研究中。
■进一步修改了沉积模型，以解释尼古丁质子化和其他影响烟雾沉积的基于香烟特定物理的机制。模型预测显示，肺部呼吸道对甲醛的总吸收（99％），尼古丁（80%）和苯并[a]芘(60%)。
■沉积和吸收的位置主要取决于成分的饱和蒸气压。甲醛等高蒸气压成分优先吸收在口腔和近肺区域，而低蒸气压成分如苯并[a]芘沉积在肺深处。呼出液滴大小的模型预测，液滴保留,尼古丁滞留,醛的吸收与实验数据相比较好。
■可以将沉积模型整合到暴露评估和其他评估吸烟对健康的潜在不利影响的研究中。
