Abstract：
UNASSIGNED: Known as a major surgical complication, postoperative delirium (POD) has not been well studied in patients with intracranial atherosclerotic stenosis (ICAS). This study aimed to investigate the correlation between perioperative clinical characteristics and the occurrence of POD.
UNASSIGNED: Patients\' demographic characteristics and perioperative testing data were collected. Binary logistic regression was conducted for assessing related risk factors. A nomogram was developed to predict the occurrence of POD after percutaneous transluminal angioplasty and stenting (PTAS) in patients with ICAS.
UNASSIGNED: The occurrence of POD in this study was 30.67%. Among all the clinical and laboratory characteristics in patients, age (OR = 1.234, 95%CI = 1.004-1.517, p = 0.046), gender (OR = 5.676, 95%CI = 1.028-31.334, p = 0.046), preoperative MMSE scores (OR = 2.298, 95%CI = 1.005-5.259, p = 0.049), the degree of stenosis (OR = 6.294, 95%CI = 1.043-37.974, p = 0.045), operating time (OR = 1.088, 95%CI = 1.023-1.157, p = 0.006), and HbA1c levels (OR = 2.226, 95%CI = 1.199-4.130, p = 0.011) were the independent risk factors.
UNASSIGNED: Male patients with advanced-age, lower preoperative MMSE scores, severe stenosis, longer operating time, and higher HbA1c levels are closely related to POD after PTAS. Fully perioperative assessments may play an important role in predicting the occurrence of POD.
UNASSIGNED: Patients\' demographic characteristics and perioperative testing data were collected. Binary logistic regression was conducted for assessing related risk factors. A nomogram was developed to predict the occurrence of POD after percutaneous transluminal angioplasty and stenting (PTAS) in patients with ICAS.
UNASSIGNED: The occurrence of POD in this study was 30.67%. Among all the clinical and laboratory characteristics in patients, age (OR = 1.234, 95%CI = 1.004-1.517, p = 0.046), gender (OR = 5.676, 95%CI = 1.028-31.334, p = 0.046), preoperative MMSE scores (OR = 2.298, 95%CI = 1.005-5.259, p = 0.049), the degree of stenosis (OR = 6.294, 95%CI = 1.043-37.974, p = 0.045), operating time (OR = 1.088, 95%CI = 1.023-1.157, p = 0.006), and HbA1c levels (OR = 2.226, 95%CI = 1.199-4.130, p = 0.011) were the independent risk factors.
UNASSIGNED: Male patients with advanced-age, lower preoperative MMSE scores, severe stenosis, longer operating time, and higher HbA1c levels are closely related to POD after PTAS. Fully perioperative assessments may play an important role in predicting the occurrence of POD.
摘要：
■被称为主要的手术并发症，颅内动脉粥样硬化性狭窄(ICAS)患者术后谵妄(POD)尚未得到很好的研究.本研究旨在探讨围手术期临床特点与POD发生的相关性。
■收集患者的人口统计学特征和围手术期检测数据。采用二元Logistic回归分析评估相关危险因素。制定了列线图来预测ICAS患者经皮腔内血管成形术和支架置入术（PTAS）后POD的发生。
■本研究中POD的发生率为30.67%。在患者的所有临床和实验室特征中，年龄（OR=1.234，95CI=1.004-1.517，p=0.046），性别（OR=5.676，95CI=1.028-31.334，p=0.046），术前MMSE评分(OR=2.298,95CI=1.005-5.259,p=0.049),狭窄程度（OR=6.294，95CI=1.043-37.974，p=0.045），运行时间（OR=1.088，95CI=1.023-1.157，p=0.006），HbA1c水平(OR=2.226,95CI=1.199~4.130,p=0.011)是独立危险因素。
■高龄男性患者，术前MMSE评分较低，严重狭窄,更长的运行时间，高HbA1c水平与PTAS后POD密切相关。全面的围手术期评估可能在预测POD的发生中起重要作用。
■收集患者的人口统计学特征和围手术期检测数据。采用二元Logistic回归分析评估相关危险因素。制定了列线图来预测ICAS患者经皮腔内血管成形术和支架置入术（PTAS）后POD的发生。
■本研究中POD的发生率为30.67%。在患者的所有临床和实验室特征中，年龄（OR=1.234，95CI=1.004-1.517，p=0.046），性别（OR=5.676，95CI=1.028-31.334，p=0.046），术前MMSE评分(OR=2.298,95CI=1.005-5.259,p=0.049),狭窄程度（OR=6.294，95CI=1.043-37.974，p=0.045），运行时间（OR=1.088，95CI=1.023-1.157，p=0.006），HbA1c水平(OR=2.226,95CI=1.199~4.130,p=0.011)是独立危险因素。
■高龄男性患者，术前MMSE评分较低，严重狭窄,更长的运行时间，高HbA1c水平与PTAS后POD密切相关。全面的围手术期评估可能在预测POD的发生中起重要作用。
