PDF(Pubmed)
Abstract：
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain injury. Even if there is no direct lung damage, severe brain injury can enhance sympathetic tones on blood vessels and vascular resistance, resulting in neurogenic pulmonary edema. Conversely, lung damage can worsen brain damage by dysregulating immunity. These findings suggest the importance of brain-lung axis interactions in TBI. However, little research has been conducted on the topic. An advanced disease model using stem cell technology may be an alternative for investigating the brain and lungs simultaneously but separately, as they can be potential candidates for improving the clinical outcomes of TBI.In this review, we describe the importance of brain-lung axis interactions in TBI by focusing on the concepts and reproducibility of brain and lung organoids in vitro. We also summarize recent research using pluripotent stem cell-derived brain organoids and their preclinical applications in various brain disease conditions and explore how they mimic the brain-lung axis. Reviewing the current status and discussing the limitations and potential perspectives in organoid research may offer a better understanding of pathophysiological interactions between the brain and lung after TBI.
摘要：
创伤性脑损伤（TBI）后的临床结果与其他器官的状况密切相关，尤其是肺部以及脑损伤的程度.即使没有直接的肺损伤，严重的脑损伤可以增强血管上的交感神经张力和血管阻力，导致神经源性肺水肿。相反，肺损伤可以通过失调的免疫力来加重脑损伤。这些发现表明脑肺轴相互作用在TBI中的重要性。然而,关于这个话题的研究很少。使用干细胞技术的高级疾病模型可能是同时但分开研究大脑和肺部的替代方法，因为它们可能是改善TBI临床结局的潜在候选者.在这次审查中,我们通过关注体外脑和肺类器官的概念和可重复性来描述脑肺轴相互作用在TBI中的重要性。我们还总结了使用多能干细胞衍生的脑类器官的最新研究及其在各种脑疾病中的临床前应用，并探索了它们如何模拟脑-肺轴。回顾当前状态并讨论类器官研究的局限性和潜在观点可能会更好地了解TBI后脑和肺之间的病理生理相互作用。
