PDF(Pubmed)
Abstract：
BACKGROUND: Migraine has been associated with mental disorders, however whether parental migraine is associated with an increased risk of major mental disorders (MMDs) in offspring has not been investigated. We aimed to examine the risk of the development of MMDs in the offspring of parents with migraine compared with those of parents without migraine.
METHODS: This study used data derived from the Taiwan National Health Insurance Research Database. Offspring of parents with migraine and a control group consisting of offspring of parents without migraine matched for demographic and parental mental disorders were included. Cox regression was used to estimate the risk of MMDs, including schizophrenia, depressive disorder, bipolar disorder, autistic spectrum disorder (ASD), and attention deficit/hyperactivity disorder (ADHD). Sub-analyses stratified by the fathers and mothers were further performed to separately clarify the risks of MMDs among the offspring.
RESULTS: We included 22,747 offspring of parents with migraine and 227,470 offspring of parents without migraine as the controls. Parental migraine was significantly associated with an increased risk of ADHD (reported as hazard ratios with 95% confidence intervals: 1.37, 1.25-1.50), bipolar disorder (1.35, 1.06-1.71), and depressive disorder (1.33, 1.21-1.47) compared to the offspring of parents without migraine. Importantly, sub-analyses showed that only maternal migraine was significantly associated with these risks.
CONCLUSIONS: Due to the heavy burden of MMDs, healthcare workers should be aware of the risk of MMDs in the offspring of parents with migraine, particular in mothers.
METHODS: This study used data derived from the Taiwan National Health Insurance Research Database. Offspring of parents with migraine and a control group consisting of offspring of parents without migraine matched for demographic and parental mental disorders were included. Cox regression was used to estimate the risk of MMDs, including schizophrenia, depressive disorder, bipolar disorder, autistic spectrum disorder (ASD), and attention deficit/hyperactivity disorder (ADHD). Sub-analyses stratified by the fathers and mothers were further performed to separately clarify the risks of MMDs among the offspring.
RESULTS: We included 22,747 offspring of parents with migraine and 227,470 offspring of parents without migraine as the controls. Parental migraine was significantly associated with an increased risk of ADHD (reported as hazard ratios with 95% confidence intervals: 1.37, 1.25-1.50), bipolar disorder (1.35, 1.06-1.71), and depressive disorder (1.33, 1.21-1.47) compared to the offspring of parents without migraine. Importantly, sub-analyses showed that only maternal migraine was significantly associated with these risks.
CONCLUSIONS: Due to the heavy burden of MMDs, healthcare workers should be aware of the risk of MMDs in the offspring of parents with migraine, particular in mothers.
摘要：
背景：偏头痛与精神障碍有关，然而,父母的偏头痛是否与后代患严重精神障碍(MMDs)的风险增加有关,目前尚未进行研究.我们旨在研究与没有偏头痛的父母相比，患有偏头痛的父母的后代发生MMD的风险。
方法：本研究使用来自台湾国民健康保险研究数据库的数据。包括患有偏头痛的父母的后代和由没有偏头痛的父母的后代组成的对照组，这些父母的后代与人口统计学和父母的精神障碍相匹配。Cox回归用于估计MMD的风险，包括精神分裂症,抑郁症,双相情感障碍,自闭症谱系障碍（ASD），注意缺陷/多动障碍（ADHD）。进一步进行了由父亲和母亲分层的子分析，以分别阐明后代中MMD的风险。
结果：我们纳入了患有偏头痛的父母的22,747个后代和没有偏头痛的父母的227,470个后代作为对照。父母偏头痛与ADHD风险增加显著相关(报告为95%置信区间的风险比:1.37,1.25-1.50),双相情感障碍（1.35，1.06-1.71），与没有偏头痛的父母的后代相比，抑郁症（1.33，1.21-1.47）。重要的是,亚分析显示,只有母体偏头痛与这些风险显著相关.
结论：由于MMD的沉重负担，医护人员应该意识到患有偏头痛的父母后代的MMD风险，尤其是母亲。
方法：本研究使用来自台湾国民健康保险研究数据库的数据。包括患有偏头痛的父母的后代和由没有偏头痛的父母的后代组成的对照组，这些父母的后代与人口统计学和父母的精神障碍相匹配。Cox回归用于估计MMD的风险，包括精神分裂症,抑郁症,双相情感障碍,自闭症谱系障碍（ASD），注意缺陷/多动障碍（ADHD）。进一步进行了由父亲和母亲分层的子分析，以分别阐明后代中MMD的风险。
结果：我们纳入了患有偏头痛的父母的22,747个后代和没有偏头痛的父母的227,470个后代作为对照。父母偏头痛与ADHD风险增加显著相关(报告为95%置信区间的风险比:1.37,1.25-1.50),双相情感障碍（1.35，1.06-1.71），与没有偏头痛的父母的后代相比，抑郁症（1.33，1.21-1.47）。重要的是,亚分析显示,只有母体偏头痛与这些风险显著相关.
结论：由于MMD的沉重负担，医护人员应该意识到患有偏头痛的父母后代的MMD风险，尤其是母亲。
