PDF(Pubmed)
Abstract：
BACKGROUND: Increased intake of specific vitamins has been linked to a decreased prevalence of osteoporosis. However, the association between dietary folate intake and the risk of osteoporosis in the general population remains incompletely understood. Therefore, we aimed to determine the association between dietary folate intake and the risk of osteoporosis in the general population of the USA.
METHODS: In this cross-sectional study, data from the National Health and Nutrition Examination Survey (2017-2020) were collected. Osteoporosis was considered to be indicated by a bone mineral density greater than 2.5 standard deviations below the mean of the young adult reference group. Dietary folate intake was measured by a 24-hour dietary recall. Multivariate logistic regression models and restricted cubic spline models were used.
RESULTS: The study included 2297 participants (mean age: 63.69 ± 0.35 years), 49.92% of whom were female. In the general population, increased dietary folate intake was directly associated with a decreased risk of osteoporosis (P for trend = 0.005). In the age > 60 years and female subgroups, folate intake was inversely associated with the risk of osteoporosis (P for trend < 0.001). The dose‒response curve suggested that this association was nonlinear (P for nonlinearity = 0.015).
CONCLUSIONS: Our cross-sectional study provides initial insights into the inverse association between dietary folate intake and the risk of osteoporosis in the general U.S.
METHODS: Further research is needed to confirm these associations.
METHODS: In this cross-sectional study, data from the National Health and Nutrition Examination Survey (2017-2020) were collected. Osteoporosis was considered to be indicated by a bone mineral density greater than 2.5 standard deviations below the mean of the young adult reference group. Dietary folate intake was measured by a 24-hour dietary recall. Multivariate logistic regression models and restricted cubic spline models were used.
RESULTS: The study included 2297 participants (mean age: 63.69 ± 0.35 years), 49.92% of whom were female. In the general population, increased dietary folate intake was directly associated with a decreased risk of osteoporosis (P for trend = 0.005). In the age > 60 years and female subgroups, folate intake was inversely associated with the risk of osteoporosis (P for trend < 0.001). The dose‒response curve suggested that this association was nonlinear (P for nonlinearity = 0.015).
CONCLUSIONS: Our cross-sectional study provides initial insights into the inverse association between dietary folate intake and the risk of osteoporosis in the general U.S.
METHODS: Further research is needed to confirm these associations.
摘要：
背景：特定维生素的摄入增加与骨质疏松症患病率降低有关。然而,一般人群中膳食叶酸摄入量与骨质疏松风险之间的关系仍未完全了解.因此,我们的目的是在美国普通人群中确定膳食叶酸摄入量与骨质疏松症风险之间的关系.
方法：在这项横断面研究中，收集了国家健康和营养检查调查(2017-2020)的数据.骨质疏松被认为是由骨矿物质密度比年轻成人参考组的平均值低2.5个标准偏差来指示的。通过24小时饮食回忆来测量饮食叶酸摄入量。使用多变量逻辑回归模型和有限三次样条模型。
结果：该研究包括2297名参与者（平均年龄：63.69±0.35岁），其中49.92%是女性。在一般人群中,膳食叶酸摄入量增加与骨质疏松风险降低直接相关(趋势P=0.005).在年龄>60岁和女性亚组中，叶酸摄入量与骨质疏松风险呈负相关(P<0.001).剂量-反应曲线表明这种关联是非线性的（非线性的P=0.015）。
结论：我们的横断面研究提供了关于一般美国饮食中叶酸摄入量与骨质疏松症风险之间的负相关的初步见解
方法：需要进一步的研究来确认这些关联。
方法：在这项横断面研究中，收集了国家健康和营养检查调查(2017-2020)的数据.骨质疏松被认为是由骨矿物质密度比年轻成人参考组的平均值低2.5个标准偏差来指示的。通过24小时饮食回忆来测量饮食叶酸摄入量。使用多变量逻辑回归模型和有限三次样条模型。
结果：该研究包括2297名参与者（平均年龄：63.69±0.35岁），其中49.92%是女性。在一般人群中,膳食叶酸摄入量增加与骨质疏松风险降低直接相关(趋势P=0.005).在年龄>60岁和女性亚组中，叶酸摄入量与骨质疏松风险呈负相关(P<0.001).剂量-反应曲线表明这种关联是非线性的（非线性的P=0.015）。
结论：我们的横断面研究提供了关于一般美国饮食中叶酸摄入量与骨质疏松症风险之间的负相关的初步见解
方法：需要进一步的研究来确认这些关联。
