Abstract：
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious respiratory disorders caused by a variety of intrapulmonary and extrapulmonary factors. Their incidence is increasing year by year, with high morbidity and mortality rates and lack of effective treatment. Inflammation plays a crucial role in ALI development, with sphingosine kinase 1 (SphK1) being a pivotal enzyme influencing sphingolipid metabolism and participating in inflammatory responses. However, the specific impact and the signaling pathway underlying SphK1 in lipopolysaccharide (LPS)-induced ALI/ARDS are poorly understood. This investigation aimed to explore the influence of SphK1 on inflammation and delve into the mechanistic aspects of inflammation in RAW 264.7 cells during LPS-induced ALI, which is of great importance in providing new targets and strategies for ALI/ARDS treatment.
摘要：
急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）是由多种肺内和肺外因素引起的严重呼吸系统疾病。它们的发病率逐年上升,高发病率和死亡率，缺乏有效的治疗方法。炎症在ALI的发展中起着至关重要的作用，鞘氨醇激酶1（SphK1）是影响鞘脂代谢并参与炎症反应的关键酶。然而,对SphK1在脂多糖(LPS)诱导的ALI/ARDS中的具体影响和信号通路了解甚少。本研究旨在探讨SphK1对炎症的影响，并探讨LPS诱导的ALI过程中RAW264.7细胞炎症的机制。这对于为ALI/ARDS治疗提供新的靶点和策略非常重要。
