Abstract：
The microbiome plays a substantial role in the efficacy of immune checkpoint blockade (ICB) in patients with metastatic melanoma. While the exact gut microbiome composition and the pathways involved in this interaction are not clearly delineated, novel studies and ongoing clinical trials are likely to reveal findings applicable to the clinical setting for the prediction and optimization of response to ICB. Nevertheless, lifestyle modifications, including high fiber diet, avoidance of unnecessary antibiotic prescriptions, and careful use of probiotics may be helpful to optimize the \"health\" of the gut microbiome and potentially enhance response to ICB in patients with melanoma.
摘要：
微生物组在转移性黑色素瘤患者的免疫检查点阻断（ICB）的功效中起着重要作用。虽然确切的肠道微生物组组成和参与这种相互作用的途径没有明确描述，新的研究和正在进行的临床试验可能揭示适用于临床环境的结果,以预测和优化对ICB的反应.然而，改变生活方式,包括高纤维饮食，避免不必要的抗生素处方，谨慎使用益生菌可能有助于优化肠道微生物组的“健康”，并可能增强黑色素瘤患者对ICB的反应。
