Abstract：
Heart failure (HF) has emerged as the most pressing health concerns globally, and extant clinical therapies are accompanied by side effects and patients have a high burden of financial. The protein products of nuclear factor erythroid 2-related factor 2 (Nrf2) target genes have a variety of cardioprotective effects, including antioxidant, metabolic functions and anti-inflammatory. By evaluating established preclinical and clinical research in HF to date, we explored the potential of Nrf2 to exert unique cardioprotective functions as a novel therapeutic receptor for HF. In this review, we generalize the progression, structure, and function of Nrf2 research in the cardiovascular system. The mechanism of action of Nrf2 involved in HF as well as agonists of Nrf2 in natural compounds are summarized. Additionally, we discuss the challenges and implications for future clinical translation and application of pharmacology targeting Nrf2. It\'s critical to developing new drugs for HF.
摘要：
心力衰竭（HF）已成为全球最紧迫的健康问题，现有的临床疗法伴随着副作用，患者的经济负担很高。核因子2相关因子2(Nrf2)靶基因的蛋白产物具有多种心脏保护作用,包括抗氧化剂，代谢功能和抗炎。通过评估迄今为止已建立的HF临床前和临床研究，我们探索了Nrf2作为HF的新型治疗受体发挥独特心脏保护功能的潜力。在这次审查中,我们概括了进展，结构,和Nrf2在心血管系统中的功能研究。总结了Nrf2参与HF的作用机理以及天然化合物中Nrf2的激动剂。此外,我们讨论了针对Nrf2的药理学的未来临床翻译和应用的挑战和意义。这对开发HF的新药至关重要。
