Abstract：
BACKGROUND: Peripartum cardiomyopathy (PPCM), a form of heart failure with reduced ejection fraction (HFrEF) that occurs during the final month of pregnancy through the first 5 months postpartum, is associated with heightened risk for maternal morbidity and mortality. Stroke is a common complication of HFrEF but there is limited data on the incidence of stroke in PPCM.
METHODS: Using statewide, nonfederal administrative data from 2000 to 2015, we analyzed age-adjusted risk of stroke within 3 years after PPCM-associated pregnancies.
RESULTS: PPCM was associated with a greater than 4-fold increased risk of pregnancy-related stroke (aHR 4.7, 95% CI: 3.0-7.5). This risk was highest at the time of PPCM diagnosis but remained elevated in the first postpartum year.
CONCLUSIONS: Our findings confirm the strong association between PPCM and stroke, with risk that persists throughout and after the peripartum period.
METHODS: Using statewide, nonfederal administrative data from 2000 to 2015, we analyzed age-adjusted risk of stroke within 3 years after PPCM-associated pregnancies.
RESULTS: PPCM was associated with a greater than 4-fold increased risk of pregnancy-related stroke (aHR 4.7, 95% CI: 3.0-7.5). This risk was highest at the time of PPCM diagnosis but remained elevated in the first postpartum year.
CONCLUSIONS: Our findings confirm the strong association between PPCM and stroke, with risk that persists throughout and after the peripartum period.
摘要：
背景：围产期心肌病（PPCM），一种在妊娠最后一个月至产后前5个月发生的射血分数（HFrEF）降低的心力衰竭形式，与孕产妇发病率和死亡率的风险增加有关。卒中是HFrEF的常见并发症，但PPCM中卒中发生率的数据有限。
方法：使用全州范围，根据2000-2015年的非联邦行政数据,我们分析了PPCM相关妊娠后3年内的年龄校正卒中风险.
结果：PPCM与妊娠相关卒中风险增加4倍以上相关(aHR4.7,95%CI:3.0-7.5)。这种风险在PPCM诊断时最高，但在产后第一年仍然升高。
结论：我们的发现证实了PPCM与卒中之间的强关联，在整个围产期和之后持续存在的风险。
方法：使用全州范围，根据2000-2015年的非联邦行政数据,我们分析了PPCM相关妊娠后3年内的年龄校正卒中风险.
结果：PPCM与妊娠相关卒中风险增加4倍以上相关(aHR4.7,95%CI:3.0-7.5)。这种风险在PPCM诊断时最高，但在产后第一年仍然升高。
结论：我们的发现证实了PPCM与卒中之间的强关联，在整个围产期和之后持续存在的风险。
