Abstract：
OBJECTIVE: The analysis of long-term trends of mortality from epilepsy has not been conducted, which is crucial for estimating the future burden of epilepsy. We therefore aimed to investigate the long-term trends of mortality from epilepsy in the United States from 1979 to 2021.
METHODS: The cause-of-death and demographic data were from the National Center for Health Statistics (1979-2021) and population estimates were from the US Census Bureau. We used the joinpoint regression model to analyze secular trends in the mortality of epilepsy spanning from 1979 to 2021. Age-adjusted mortality from epilepsy was assessed based on the year 2000 U.S. population data, stratified by age, sex, and race.
RESULTS: The age-adjusted mortality from epilepsy increased from 0.78 per 100,000 population in 1979 to 1.01 per 100,000 population in 2021, with an average annual percent change (AAPC) of 0.58% (95% confidence interval [CI]: 0.45% - 0.72%). The overall age-adjusted mortality of epilepsy had been on the rise between 2011 and 2021. The mortality rate generally increases with age. The mortality of epilepsy was higher in the Afro-American people and men. The mortality of epilepsy in both sexes declined first and then increased, with AAPC 1.02% (95% CI: 0.88%, 1.23%) in women and 0.10% (95% CI: -0.002%, 0.21%) in men. Mortality in all races including White, Afro-American people, and other races individuals fell first and then rose. The AAPC of mortality in White, other races, and Afro-American people were 0.89% (95% CI: 0.79%, 1.02%), -0.87% (95% CI: -1.84%, 0.88%), and -0.31% (95% CI: -0.48%, -0.13%), respectively.
CONCLUSIONS: Although the mortality rate from epilepsy has experienced a period of decline, it is worth noting that the last decade has seen a rapid increase. A comprehensive assessment of long-term trends in mortality from epilepsy holds significance for healthcare prioritization.
METHODS: The cause-of-death and demographic data were from the National Center for Health Statistics (1979-2021) and population estimates were from the US Census Bureau. We used the joinpoint regression model to analyze secular trends in the mortality of epilepsy spanning from 1979 to 2021. Age-adjusted mortality from epilepsy was assessed based on the year 2000 U.S. population data, stratified by age, sex, and race.
RESULTS: The age-adjusted mortality from epilepsy increased from 0.78 per 100,000 population in 1979 to 1.01 per 100,000 population in 2021, with an average annual percent change (AAPC) of 0.58% (95% confidence interval [CI]: 0.45% - 0.72%). The overall age-adjusted mortality of epilepsy had been on the rise between 2011 and 2021. The mortality rate generally increases with age. The mortality of epilepsy was higher in the Afro-American people and men. The mortality of epilepsy in both sexes declined first and then increased, with AAPC 1.02% (95% CI: 0.88%, 1.23%) in women and 0.10% (95% CI: -0.002%, 0.21%) in men. Mortality in all races including White, Afro-American people, and other races individuals fell first and then rose. The AAPC of mortality in White, other races, and Afro-American people were 0.89% (95% CI: 0.79%, 1.02%), -0.87% (95% CI: -1.84%, 0.88%), and -0.31% (95% CI: -0.48%, -0.13%), respectively.
CONCLUSIONS: Although the mortality rate from epilepsy has experienced a period of decline, it is worth noting that the last decade has seen a rapid increase. A comprehensive assessment of long-term trends in mortality from epilepsy holds significance for healthcare prioritization.
摘要：
目的：尚未对癫痫死亡率的长期趋势进行分析，这对于估计癫痫的未来负担至关重要。因此，我们旨在调查1979年至2021年美国癫痫死亡率的长期趋势。
方法：死因和人口统计数据来自美国国家卫生统计中心（1979-2021），人口估计来自美国人口普查局。我们使用连接点回归模型分析了1979年至2021年癫痫死亡率的长期趋势。根据2000年美国人口数据评估了年龄调整后的癫痫死亡率，按年龄分层，性别,和种族。
结果：年龄调整后的癫痫死亡率从1979年的每100,000人0.78增加到2021年的每100,000人1.01，平均年变化百分比（AAPC）为0.58％（95％置信区间[CI]：0.45％-0.72％）。2011年至2021年期间，癫痫的总体年龄调整后死亡率一直在上升。死亡率通常随年龄增长而增加。非洲裔美国人和男性的癫痫死亡率较高。两性癫痫的死亡率先下降后上升,AAPC1.02%（95%CI：0.88%，女性1.23%）和0.10%（95%CI：-0.002%，0.21%)在男性中。包括怀特在内的所有种族的死亡率,美国黑人,和其他种族个人先下降，然后上升。白人死亡率的AAPC，其他种族,美国黑人为0.89%(95%CI：0.79%，1.02%），-0.87%（95%CI：-1.84%，0.88%），和-0.31%（95%CI：-0.48%，-0.13%），分别。
结论：尽管癫痫死亡率经历了一段时间的下降，值得注意的是，在过去的十年中，增长迅速。对癫痫死亡率的长期趋势进行全面评估对于确定医疗保健优先级具有重要意义。
方法：死因和人口统计数据来自美国国家卫生统计中心（1979-2021），人口估计来自美国人口普查局。我们使用连接点回归模型分析了1979年至2021年癫痫死亡率的长期趋势。根据2000年美国人口数据评估了年龄调整后的癫痫死亡率，按年龄分层，性别,和种族。
结果：年龄调整后的癫痫死亡率从1979年的每100,000人0.78增加到2021年的每100,000人1.01，平均年变化百分比（AAPC）为0.58％（95％置信区间[CI]：0.45％-0.72％）。2011年至2021年期间，癫痫的总体年龄调整后死亡率一直在上升。死亡率通常随年龄增长而增加。非洲裔美国人和男性的癫痫死亡率较高。两性癫痫的死亡率先下降后上升,AAPC1.02%（95%CI：0.88%，女性1.23%）和0.10%（95%CI：-0.002%，0.21%)在男性中。包括怀特在内的所有种族的死亡率,美国黑人,和其他种族个人先下降，然后上升。白人死亡率的AAPC，其他种族,美国黑人为0.89%(95%CI：0.79%，1.02%），-0.87%（95%CI：-1.84%，0.88%），和-0.31%（95%CI：-0.48%，-0.13%），分别。
结论：尽管癫痫死亡率经历了一段时间的下降，值得注意的是，在过去的十年中，增长迅速。对癫痫死亡率的长期趋势进行全面评估对于确定医疗保健优先级具有重要意义。
