Abstract：
New advancements in medicine have paved the way for targeted therapies and immune checkpoint inhibitors (ICIs), which have become mainstays of cancer therapy. Targeted therapies work by pinpointing specific molecules in cancer pathways and inhibiting their function, while ICIs target irregularities in the immune system and DNA repair, participating in the induction of cell death. Although these agents have demonstrated great efficacy in treating a diverse set of cancers, they can frequently provoke serious dermatologic adverse effects. The side effects caused by an ICI are classified as immune-related adverse events since ICIs are immunomodulating, while the cutaneous side effects of targeted therapies are known as dermatologic adverse effects. Multiple studies have reported psoriasis and psoriasiform eruptions among the side effects observed in neoplastic patients receiving targeted therapies or ICIs. Psoriasis is an immune-mediated disease characterized by overactive T-cells and keratinocytes. To conduct this review, we retrieved 1363 studies from the PubMed database published between 2008 and 2023 using the terms \"psoriasis\" AND \"cancer treatment.\" Many of these studies aimed to understand how patients with cancer receiving treatment may develop or even achieve psoriasis remission. Given that cancer and psoriasis involve a delicate balance between immune activation and suppression, ICIs and targeted therapies might produce varying effects. The aim of this review was to explore the relationship between psoriasis and cancer therapeutics while also highlighting the need to prioritize proper management of cutaneous side effects in neoplastic patients.
摘要：
医学的新进展为靶向治疗和免疫检查点抑制剂（ICIs）铺平了道路。已经成为癌症治疗的支柱。靶向治疗通过在癌症通路中精确定位特定分子并抑制其功能来发挥作用，虽然ICI针对免疫系统和DNA修复的不规则性，参与诱导细胞死亡。尽管这些药物在治疗多种癌症方面表现出了巨大的疗效，它们经常会引起严重的皮肤病不良反应。由ICI引起的副作用被归类为免疫相关的不良事件，因为ICI是免疫调节的，而靶向治疗的皮肤副作用被称为皮肤病不良反应。多项研究报道了在接受靶向治疗或ICIs的肿瘤患者中观察到的副作用中的牛皮癣和银屑病样爆发。银屑病是一种以过度活跃的T细胞和角质形成细胞为特征的免疫介导的疾病。为了进行这次审查，我们从PubMed数据库检索了2008年至2023年间发表的1363项研究,使用术语"银屑病"和"癌症治疗".“这些研究中的许多研究旨在了解接受治疗的癌症患者如何发展甚至实现牛皮癣缓解。鉴于癌症和牛皮癣涉及免疫激活和抑制之间的微妙平衡，ICI和靶向治疗可能会产生不同的效果。这篇综述的目的是探索银屑病与癌症治疗之间的关系，同时强调需要优先考虑肿瘤患者皮肤副作用的适当管理。
