Abstract：
OBJECTIVE: The purpose of this study was to investigate whether people with fibromyalgia (FM) have dysfunctional breathing by examining acid-base balance and comparing it with healthy controls.
METHODS: Thirty-six women diagnosed with FM and 36 healthy controls matched for age and gender participated in this cross-sectional study. To evaluate acid-base balance, arterial blood was sampled from the radial artery. Carbon dioxide, oxygen, bicarbonate, base excess, pH and lactate were analysed for between-group differences. Blood gas analyses were performed stepwise on each individual to detect acid-base disturbance, which was categorized as primary respiratory and possible compensation indicating chronicity. A three-step approach was employed to evaluate pH, carbon dioxide and bicarbonate in this order.
RESULTS: Women with FM had significantly lower carbon dioxide pressure (p = 0.013) and higher lactate (p = 0.038) compared to healthy controls at the group level. There were no significant differences in oxygen pressure, bicarbonate, pH and base excess. Employing a three-step acid-base analysis, 11 individuals in the FM group had a possible renally compensated mild chronic hyperventilation, compared to only 4 among the healthy controls (p = 0.042).
CONCLUSIONS: In this study, we could identify a subgroup of individuals with FM who may be characterized as mild chronic hyperventilators. The results might point to a plausible dysfunctional breathing in some women with FM.
METHODS: Thirty-six women diagnosed with FM and 36 healthy controls matched for age and gender participated in this cross-sectional study. To evaluate acid-base balance, arterial blood was sampled from the radial artery. Carbon dioxide, oxygen, bicarbonate, base excess, pH and lactate were analysed for between-group differences. Blood gas analyses were performed stepwise on each individual to detect acid-base disturbance, which was categorized as primary respiratory and possible compensation indicating chronicity. A three-step approach was employed to evaluate pH, carbon dioxide and bicarbonate in this order.
RESULTS: Women with FM had significantly lower carbon dioxide pressure (p = 0.013) and higher lactate (p = 0.038) compared to healthy controls at the group level. There were no significant differences in oxygen pressure, bicarbonate, pH and base excess. Employing a three-step acid-base analysis, 11 individuals in the FM group had a possible renally compensated mild chronic hyperventilation, compared to only 4 among the healthy controls (p = 0.042).
CONCLUSIONS: In this study, we could identify a subgroup of individuals with FM who may be characterized as mild chronic hyperventilators. The results might point to a plausible dysfunctional breathing in some women with FM.
摘要：
目的：这项研究的目的是通过检查酸碱平衡并将其与健康对照进行比较来调查纤维肌痛（FM）患者是否有呼吸功能失调。
方法：36名诊断为FM的妇女和36名年龄和性别相匹配的健康对照者参与了这项横断面研究。要评估酸碱平衡，从桡动脉采集动脉血。二氧化碳,氧气,碳酸氢盐,碱过量，分析pH和乳酸的组间差异。对每个个体逐步进行血气分析，以检测酸碱紊乱，这被归类为原发性呼吸和可能的补偿表明慢性。采用三步法评估pH值，二氧化碳和碳酸氢盐按这个顺序。
结果：与健康对照组相比，FM女性的二氧化碳压力（p=0.013）和乳酸（p=0.038）明显降低。氧分压没有显著差异,碳酸氢盐,pH和碱过量。采用三步酸碱分析，FM组中有11个人可能患有肾脏代偿性轻度慢性换气过度，相比之下，健康对照中只有4个（p=0.042）。
结论：在这项研究中，我们可以识别出一组可能表现为轻度慢性高呼吸机患者的FM患者。结果可能表明某些FM女性的呼吸功能失调。
方法：36名诊断为FM的妇女和36名年龄和性别相匹配的健康对照者参与了这项横断面研究。要评估酸碱平衡，从桡动脉采集动脉血。二氧化碳,氧气,碳酸氢盐,碱过量，分析pH和乳酸的组间差异。对每个个体逐步进行血气分析，以检测酸碱紊乱，这被归类为原发性呼吸和可能的补偿表明慢性。采用三步法评估pH值，二氧化碳和碳酸氢盐按这个顺序。
结果：与健康对照组相比，FM女性的二氧化碳压力（p=0.013）和乳酸（p=0.038）明显降低。氧分压没有显著差异,碳酸氢盐,pH和碱过量。采用三步酸碱分析，FM组中有11个人可能患有肾脏代偿性轻度慢性换气过度，相比之下，健康对照中只有4个（p=0.042）。
结论：在这项研究中，我们可以识别出一组可能表现为轻度慢性高呼吸机患者的FM患者。结果可能表明某些FM女性的呼吸功能失调。
