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Abstract：
BACKGROUND: The accurate prediction of pregnancy outcomes in in vitro fertilization (IVF) cycles is crucial. While several studies have been conducted on the predictive power of serum estradiol (E2) and β-hCG concentrations post-embryo transfer (ET) for pregnancy outcomes, there is debate on the predictive value of E2. The objective of this study was to investigate the predictive efficacy of combining serum E2 and β-hCG levels on early reproductive outcomes 12 days after embryo transfer.
METHODS: A total of 1521 patients with β-hCG positive values on day 12 following frozen-thawed embryo transfer (FET) with natural endometrial preparation cycles (NCs) were gathered in affiliated Women\'s Hospital of Jiangnan University. Using logistic regression, the relationship between pregnancy outcome and early serum E2 and β-hCG concentrations was examined. The receiver-operating characteristic (ROC) analysis was used to assess the predictive accuracy of the serum E2 and β-hCG concentrations.
RESULTS: Notable distinctions were observed in the serum E2 and β-hCG levels on the twelfth day following FET with NCs between the groups classified as clinical pregnancy group (CP Group) and biochemical pregnancy group (BP Group). In addition, the cutoff values for E2 and β-hCG on day 12 following FET with NCs in cleavage embryo group (CE Group) were 129.25 pg/mL and 156.60 mIU/mL, respectively. The threshold values for E2 and β-hCG for the blastocyst group (B Group) were 174.45 pg/mL and 217.70 mIU/mL. Serum E2 day12 and β-hCG day12 were found to be substantially linked with clinical pregnancy by logistic regression analysis.
CONCLUSIONS: Serum E2 and β-hCG concentrations were found to be significantly different between the CP Group and BP Group in infertility women underwent FET with NCs. Our retrospective cohort study\'s findings suggest that the combination of early E2 and β-hCG levels on day 12 post-FET could be used as a predictive tool to evaluate the likelihood of both positive and negative pregnancy outcomes in FET with NCs.
METHODS: A total of 1521 patients with β-hCG positive values on day 12 following frozen-thawed embryo transfer (FET) with natural endometrial preparation cycles (NCs) were gathered in affiliated Women\'s Hospital of Jiangnan University. Using logistic regression, the relationship between pregnancy outcome and early serum E2 and β-hCG concentrations was examined. The receiver-operating characteristic (ROC) analysis was used to assess the predictive accuracy of the serum E2 and β-hCG concentrations.
RESULTS: Notable distinctions were observed in the serum E2 and β-hCG levels on the twelfth day following FET with NCs between the groups classified as clinical pregnancy group (CP Group) and biochemical pregnancy group (BP Group). In addition, the cutoff values for E2 and β-hCG on day 12 following FET with NCs in cleavage embryo group (CE Group) were 129.25 pg/mL and 156.60 mIU/mL, respectively. The threshold values for E2 and β-hCG for the blastocyst group (B Group) were 174.45 pg/mL and 217.70 mIU/mL. Serum E2 day12 and β-hCG day12 were found to be substantially linked with clinical pregnancy by logistic regression analysis.
CONCLUSIONS: Serum E2 and β-hCG concentrations were found to be significantly different between the CP Group and BP Group in infertility women underwent FET with NCs. Our retrospective cohort study\'s findings suggest that the combination of early E2 and β-hCG levels on day 12 post-FET could be used as a predictive tool to evaluate the likelihood of both positive and negative pregnancy outcomes in FET with NCs.
摘要：
背景：体外受精（IVF）周期中妊娠结局的准确预测至关重要。虽然已经对胚胎移植后血清雌二醇（E2）和β-hCG浓度（ET）对妊娠结局的预测能力进行了多项研究，关于E2的预测价值存在争议。这项研究的目的是探讨血清E2和β-hCG水平联合对胚胎移植后12天早期生殖结局的预测功效。
方法：在江南大学附属妇女医院收集了1521例采用自然子宫内膜准备周期的冻融胚胎移植（FET）后第12天β-hCG阳性的患者。使用逻辑回归，研究了妊娠结局与早期血清E2和β-hCG浓度之间的关系。受试者工作特征（ROC）分析用于评估血清E2和β-hCG浓度的预测准确性。
结果：在FET后第12天，在分为临床妊娠组（CP组）和生化妊娠组（BP组）的两组中，观察到血清E2和β-hCG水平的明显差异。此外,卵裂胚胎组（CE组）中带有NC的FET后第12天，E2和β-hCG的截止值分别为129.25pg/mL和156.60mIU/mL，分别。胚泡组（B组）的E2和β-hCG阈值分别为174.45pg/mL和217.70mIU/mL。通过逻辑回归分析发现血清E2第12天和β-hCG第12天与临床妊娠密切相关。
结论：发现CP组和BP组的血清E2和β-hCG浓度在接受NCFET的不孕症妇女中存在显著差异。我们的回顾性队列研究结果表明，FET后第12天的早期E2和β-hCG水平的组合可以用作预测工具，以评估具有NC的FET的阳性和阴性妊娠结局的可能性。
方法：在江南大学附属妇女医院收集了1521例采用自然子宫内膜准备周期的冻融胚胎移植（FET）后第12天β-hCG阳性的患者。使用逻辑回归，研究了妊娠结局与早期血清E2和β-hCG浓度之间的关系。受试者工作特征（ROC）分析用于评估血清E2和β-hCG浓度的预测准确性。
结果：在FET后第12天，在分为临床妊娠组（CP组）和生化妊娠组（BP组）的两组中，观察到血清E2和β-hCG水平的明显差异。此外,卵裂胚胎组（CE组）中带有NC的FET后第12天，E2和β-hCG的截止值分别为129.25pg/mL和156.60mIU/mL，分别。胚泡组（B组）的E2和β-hCG阈值分别为174.45pg/mL和217.70mIU/mL。通过逻辑回归分析发现血清E2第12天和β-hCG第12天与临床妊娠密切相关。
结论：发现CP组和BP组的血清E2和β-hCG浓度在接受NCFET的不孕症妇女中存在显著差异。我们的回顾性队列研究结果表明，FET后第12天的早期E2和β-hCG水平的组合可以用作预测工具，以评估具有NC的FET的阳性和阴性妊娠结局的可能性。
