Abstract：
OBJECTIVE: This study aimed to consolidate the evidence regarding the prognostic influence of sarcopenia in degenerative lumbar spine surgeries.
METHODS: A literature search of public databases was conducted up to Nov 15, 2023 using combinations of the key words \"sarcopenia\" and \"lumbar spine surgery\". Eligible studies were those that focused on adults undergoing decompression or fusion surgery for degenerative lumbar spine diseases, and compared the outcomes between patients with and without preoperative sarcopenia. Primary outcomes were change in ODI and back and leg pain VAS pain scores. Secondary outcomes were changes in Eq. 5D, JOA, SFHS-p scores, and LOS.
RESULTS: Ultimately, nine retrospective studies with a total of 993 patients were included. Sarcopenic patients exhibited significantly worse functional improvement as assessed by ODI compared to non-sarcopenic patients (pooled standardized mean difference [pSMD] = 0.53, 95% confidence interval [CI]: 0.17-0.90). Back pain (pSMD = 0.31, 95% CI:0.15-0.47) and leg pain (pSMD = 0.21, 95% CI:0.02 - 0.39) improvement were also less in sarcopenic patients. Non-sarcopenic patients had greater improvements in Eq. 5D (pSMD = 0.25) and SFHS-p (pSMD = 0.39), and shorter LOS (pSMD = 0.62).
CONCLUSIONS: As compared to patients without sarcopenia, those with sarcopenia undergoing lumbar spine surgery for degenerative diseases have lower improvements in functional ability, quality of life, physical health, pain relief and extended hospitalization compared to those without sarcopenia.
METHODS: A literature search of public databases was conducted up to Nov 15, 2023 using combinations of the key words \"sarcopenia\" and \"lumbar spine surgery\". Eligible studies were those that focused on adults undergoing decompression or fusion surgery for degenerative lumbar spine diseases, and compared the outcomes between patients with and without preoperative sarcopenia. Primary outcomes were change in ODI and back and leg pain VAS pain scores. Secondary outcomes were changes in Eq. 5D, JOA, SFHS-p scores, and LOS.
RESULTS: Ultimately, nine retrospective studies with a total of 993 patients were included. Sarcopenic patients exhibited significantly worse functional improvement as assessed by ODI compared to non-sarcopenic patients (pooled standardized mean difference [pSMD] = 0.53, 95% confidence interval [CI]: 0.17-0.90). Back pain (pSMD = 0.31, 95% CI:0.15-0.47) and leg pain (pSMD = 0.21, 95% CI:0.02 - 0.39) improvement were also less in sarcopenic patients. Non-sarcopenic patients had greater improvements in Eq. 5D (pSMD = 0.25) and SFHS-p (pSMD = 0.39), and shorter LOS (pSMD = 0.62).
CONCLUSIONS: As compared to patients without sarcopenia, those with sarcopenia undergoing lumbar spine surgery for degenerative diseases have lower improvements in functional ability, quality of life, physical health, pain relief and extended hospitalization compared to those without sarcopenia.
摘要：
目的：本研究旨在巩固肌肉减少症对腰椎退行性手术预后影响的证据。
方法：使用关键词“肌少症”和“腰椎手术”的组合对公共数据库进行了文献检索，直至2023年11月15日。符合条件的研究是那些专注于接受减压或融合手术治疗退行性腰椎疾病的成年人，并比较术前有无肌肉减少症患者的结局。主要结果是ODI和腰腿痛VAS疼痛评分的变化。次要结果是Eq的变化。5D,JOA,SFHS-p分数,还有LOS.
结果：最终，纳入了9项回顾性研究,共993例患者.通过ODI评估，与非肌少症患者相比，肌少症患者表现出明显更差的功能改善（合并标准化平均差[pSMD]=0.53，95％置信区间[CI]：0.17-0.90）。腰痛（pSMD=0.31，95％CI：0.15-0.47）和腿痛（pSMD=0.21，95％CI：0.02-0.39）的改善在肌少症患者中也较少。非肌少症患者的Eq改善更大。5D（pSMD=0.25）和SFHS-p（pSMD=0.39），和较短的LOS（pSMD=0.62）。
结论：与没有肌少症的患者相比，那些患有肌肉减少症的人接受腰椎手术治疗退行性疾病的功能改善较低，生活质量,身体健康,与没有肌肉减少症的患者相比，疼痛缓解和住院时间延长。
方法：使用关键词“肌少症”和“腰椎手术”的组合对公共数据库进行了文献检索，直至2023年11月15日。符合条件的研究是那些专注于接受减压或融合手术治疗退行性腰椎疾病的成年人，并比较术前有无肌肉减少症患者的结局。主要结果是ODI和腰腿痛VAS疼痛评分的变化。次要结果是Eq的变化。5D,JOA,SFHS-p分数,还有LOS.
结果：最终，纳入了9项回顾性研究,共993例患者.通过ODI评估，与非肌少症患者相比，肌少症患者表现出明显更差的功能改善（合并标准化平均差[pSMD]=0.53，95％置信区间[CI]：0.17-0.90）。腰痛（pSMD=0.31，95％CI：0.15-0.47）和腿痛（pSMD=0.21，95％CI：0.02-0.39）的改善在肌少症患者中也较少。非肌少症患者的Eq改善更大。5D（pSMD=0.25）和SFHS-p（pSMD=0.39），和较短的LOS（pSMD=0.62）。
结论：与没有肌少症的患者相比，那些患有肌肉减少症的人接受腰椎手术治疗退行性疾病的功能改善较低，生活质量,身体健康,与没有肌肉减少症的患者相比，疼痛缓解和住院时间延长。
