PDF(Pubmed)
Abstract：
Parabens (PBs) are used as preservatives in various products. They pollute the environment and penetrate living organisms, showing endocrine disrupting activity. Till now studies on long-term exposure of farm animals to PBs have not been performed. Among matrices using in PBs biomonitoring hair samples are becoming more and more important. During this study concentration levels of methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP) butyl paraben (BuP) and benzyl paraben (BeP) were evaluated using liquid chromatography-mass spectrometry (LC-MS) in hair samples collected from dairy cows bred in the Kyrgyz Republic. MeP was noted in 93.8% of samples (with mean concentration levels 62.2 ± 61.8 pg/mg), PrP in 16.7% of samples (12.4 ± 6.5 pg/mg) and EtP in 8.3% of samples (21.4 ± 11.9 pg/mg). BuP was found only in one sample (2.1%) and BeP was not detected in any sample included in the study. Some differences in MeP concentration levels in the hair samples depending on district, where cows were bred were noted. This study has shown that among PBs, dairy cows are exposed mainly to MeP, and hair samples may be a suitable matrix for research on PBs levels in farm animals.
摘要：
对羟基苯甲酸酯(PBs)在各种产品中用作防腐剂。它们污染环境并穿透生物体，显示内分泌干扰活动。到目前为止，尚未进行有关农场动物长期暴露于PBs的研究。在PBs中使用的基质生物监测头发样品变得越来越重要。在这项研究中，对羟基苯甲酸甲酯（MeP）的浓度水平，对羟基苯甲酸乙酯（EtP），使用液相色谱-质谱（LC-MS）对吉尔吉斯共和国饲养的奶牛的头发样品中的对羟基苯甲酸丙酯（PrP）对羟基苯甲酸丁酯（BuP）和对羟基苯甲酸苄酯（BeP）进行了评估。在93.8％的样品中发现了MeP（平均浓度水平为62.2±61.8pg/mg），16.7%的样品中的PrP(12.4±6.5μg/mg)和8.3%的样品中的EtP(21.4±11.9μg/mg)。仅在一个样品(2.1%)中发现BuP,并且在包括在研究中的任何样品中未检测到BeP。头发样本中MeP浓度水平的一些差异取决于地区，注意到奶牛的饲养地点。这项研究表明，在PB中，奶牛主要暴露于MeP，和毛发样品可能是研究农场动物中PBs水平的合适基质。
