Abstract：
OBJECTIVE: Little is known regarding the association between chronic tonsillitis and the onset of IgA nephropathy (IgAN). In the present study, we examined the potential relationship between chronic tonsillitis and a subsequent risk of developing IgAN.
METHODS: Observational cohort study.
METHODS: 4,311,393 individuals without a history of IgAN identified between January 2005 and May 2022 within a Japanese nationwide epidemiological database, the JMDC Claims Database, representing health claims to over 60 insurers.
METHODS: Comorbid chronic tonsillitis based on diagnosis codes.
RESULTS: IgAN occurrence.
METHODS: Cause-specific Cox proportional hazards analysis adjusting for potential confounding factors was employed to estimate hazard ratios (HRs).
RESULTS: Comorbid chronic tonsillitis was identified in 12,842 individuals, constituting 0.3% of the cohort. The cohort had a median age of 44 years (IQR, 36-53), and males accounted for 57.9%, with a follow-up of 1,089 days (IQR, 532-1,797), during which 2,653 cases of IgAN developed. Cumulative incidence curve showed a higher cumulative incidence of IgAN in individuals with chronic tonsillitis compared with their counterparts without this condition. Multivariable cause-specific analysis further demonstrated that individuals with chronic tonsillitis had an elevated risk of developing IgAN, with HR of 2.72 (95% CI, 1.79-4.14).
CONCLUSIONS: Potential residual confounders, and lack of consideration for ethnic distinctions.
CONCLUSIONS: Using a large-scale epidemiological dataset, these findings suggest a relationship between chronic tonsillitis and an elevated risk of IgAN development in the general Japanese population.
UNASSIGNED: IgA nephropathy (IgAN), the most prevalent form of primary glomerulonephritis worldwide, is associated with unfavorable long-term kidney survival and life expectancy. Despite the substantial implications, the early detection of IgAN still remains challenging due to its commonly asymptomatic clinical presentation. Consequently, the exploration of risk factors assumes a critical research priority. Prior studies have reported the potential role of tonsilitis in the pathogenesis of IgAN. In this study, we assessed whether chronic tonsillitis was associated with the subsequent development of IgAN using a nationwide epidemiological dataset incorporating over 4,000,000 individuals. Within this large-scale cohort, our findings revealed an association between a history of tonsillitis and a greater risk of developing IgAN. These findings should heighten awareness of the potential susceptibility of people with chronic tonsilitis to IgAN.
METHODS: Observational cohort study.
METHODS: 4,311,393 individuals without a history of IgAN identified between January 2005 and May 2022 within a Japanese nationwide epidemiological database, the JMDC Claims Database, representing health claims to over 60 insurers.
METHODS: Comorbid chronic tonsillitis based on diagnosis codes.
RESULTS: IgAN occurrence.
METHODS: Cause-specific Cox proportional hazards analysis adjusting for potential confounding factors was employed to estimate hazard ratios (HRs).
RESULTS: Comorbid chronic tonsillitis was identified in 12,842 individuals, constituting 0.3% of the cohort. The cohort had a median age of 44 years (IQR, 36-53), and males accounted for 57.9%, with a follow-up of 1,089 days (IQR, 532-1,797), during which 2,653 cases of IgAN developed. Cumulative incidence curve showed a higher cumulative incidence of IgAN in individuals with chronic tonsillitis compared with their counterparts without this condition. Multivariable cause-specific analysis further demonstrated that individuals with chronic tonsillitis had an elevated risk of developing IgAN, with HR of 2.72 (95% CI, 1.79-4.14).
CONCLUSIONS: Potential residual confounders, and lack of consideration for ethnic distinctions.
CONCLUSIONS: Using a large-scale epidemiological dataset, these findings suggest a relationship between chronic tonsillitis and an elevated risk of IgAN development in the general Japanese population.
UNASSIGNED: IgA nephropathy (IgAN), the most prevalent form of primary glomerulonephritis worldwide, is associated with unfavorable long-term kidney survival and life expectancy. Despite the substantial implications, the early detection of IgAN still remains challenging due to its commonly asymptomatic clinical presentation. Consequently, the exploration of risk factors assumes a critical research priority. Prior studies have reported the potential role of tonsilitis in the pathogenesis of IgAN. In this study, we assessed whether chronic tonsillitis was associated with the subsequent development of IgAN using a nationwide epidemiological dataset incorporating over 4,000,000 individuals. Within this large-scale cohort, our findings revealed an association between a history of tonsillitis and a greater risk of developing IgAN. These findings should heighten awareness of the potential susceptibility of people with chronic tonsilitis to IgAN.
摘要：
目的：关于慢性扁桃体炎与IgA肾病（IgAN）发病之间的关系知之甚少。在本研究中,我们研究了慢性扁桃体炎与随后发生IgAN的风险之间的潜在关系.
方法：观察性队列研究。
方法：&参与者：2005年1月至2022年5月在日本全国流行病学数据库中确定的4,311,393名没有IgAN病史的人，JMDC声明数据库，代表60多家保险公司的健康索赔。
方法：基于诊断代码的慢性扁桃体炎。
结果：IgAN发生。
方法：采用对潜在混杂因素进行调整的特定原因Cox比例风险分析来估计风险比（HR）。
结果：在12,842个人中发现了Comorbid慢性扁桃体炎，占队列的0.3%。该队列的中位年龄为44岁（四分位距：36-53），男性占57.9%，随访1,089天（四分位距：532-1,797），在此期间发生了2653例IgAN。累积发病率曲线显示，与没有这种情况的人相比，慢性扁桃体炎患者的IgAN累积发病率更高。多变量病因分析进一步表明，慢性扁桃体炎患者发生IgAN的风险升高，HR为2.72（95%置信区间：1.79-4.14）。
结论：潜在的残余混杂因素，缺乏对民族差别的考虑。
结论：使用大规模流行病学数据集，这些发现提示,在日本普通人群中,慢性扁桃体炎与IgAN发展风险升高之间存在相关性.
方法：观察性队列研究。
方法：&参与者：2005年1月至2022年5月在日本全国流行病学数据库中确定的4,311,393名没有IgAN病史的人，JMDC声明数据库，代表60多家保险公司的健康索赔。
方法：基于诊断代码的慢性扁桃体炎。
结果：IgAN发生。
方法：采用对潜在混杂因素进行调整的特定原因Cox比例风险分析来估计风险比（HR）。
结果：在12,842个人中发现了Comorbid慢性扁桃体炎，占队列的0.3%。该队列的中位年龄为44岁（四分位距：36-53），男性占57.9%，随访1,089天（四分位距：532-1,797），在此期间发生了2653例IgAN。累积发病率曲线显示，与没有这种情况的人相比，慢性扁桃体炎患者的IgAN累积发病率更高。多变量病因分析进一步表明，慢性扁桃体炎患者发生IgAN的风险升高，HR为2.72（95%置信区间：1.79-4.14）。
结论：潜在的残余混杂因素，缺乏对民族差别的考虑。
结论：使用大规模流行病学数据集，这些发现提示,在日本普通人群中,慢性扁桃体炎与IgAN发展风险升高之间存在相关性.
