Abstract：
OBJECTIVE: To examine the incidence and risk factors of proliferative vitreoretinopathy (PVR) in the patients who develop rhegmatogenous retinal detachment (RRD) in their fellow eye after having a prior RRD complicated by PVR.
METHODS: Multicenter, retrospective observational study.
METHODS: Eyes with retinal detachment and PVR between 2015 and 2023 were identified through the Vestrum Health Database METHODS: Risk factors for PVR development, specifically documented PVR in the fellow eye, gender, age, lens status, and presenting and final visual acuity, were evaluated.
METHODS: Odds ratio for PVR development during 6 months post-operative period.
RESULTS: Of 57,264 patients, 11% had PVR in at least one eye. Of the 50,989 patients who did not develop PVR after the initial RRD, 4,834 developed RRD in the fellow eye. 166 of these patients developed PVR in their second eye for a PVR rate of 3% in the fellow eye. Of the 6,275 patients who developed PVR after primary RRD repair, 406 of these patients went on to develop RRD in their fellow eye. 42 of these patients developed PVR in their second eye for a PVR rate of 10%. A regression model that also included age, gender and visual acuity led to an odds ratio of 3.42 (p<0.001). The odds ratio of PVR development generally decreased with age. Pseudophakic patients had a higher odds ratio for PVR development, 1.48 (p=0.017). Initial patients with VA 20/40-20/80 had an odds ratio of 2.15 (p=0.003). Patients with VA worse than 20/200 had an odds ratio of 2.89 for PVR development (p<0.001).
CONCLUSIONS: Patients with a history RRD with PVR in one eye, have approximately 3.5 times higher rate of PVR in their second eye after RRD compared with patients without a history of PVR. This finding potential impacts surgical decisions and use of prophylactic anti-PVR therapy if the patient\'s second eye has RRD. The final visual acuity in second eye of patients with history PVR is better than for the second eye of patients with no history of PVR which may indicate surgeons are already taking steps to prevent PVR in the patient\'s second eye.
METHODS: Multicenter, retrospective observational study.
METHODS: Eyes with retinal detachment and PVR between 2015 and 2023 were identified through the Vestrum Health Database METHODS: Risk factors for PVR development, specifically documented PVR in the fellow eye, gender, age, lens status, and presenting and final visual acuity, were evaluated.
METHODS: Odds ratio for PVR development during 6 months post-operative period.
RESULTS: Of 57,264 patients, 11% had PVR in at least one eye. Of the 50,989 patients who did not develop PVR after the initial RRD, 4,834 developed RRD in the fellow eye. 166 of these patients developed PVR in their second eye for a PVR rate of 3% in the fellow eye. Of the 6,275 patients who developed PVR after primary RRD repair, 406 of these patients went on to develop RRD in their fellow eye. 42 of these patients developed PVR in their second eye for a PVR rate of 10%. A regression model that also included age, gender and visual acuity led to an odds ratio of 3.42 (p<0.001). The odds ratio of PVR development generally decreased with age. Pseudophakic patients had a higher odds ratio for PVR development, 1.48 (p=0.017). Initial patients with VA 20/40-20/80 had an odds ratio of 2.15 (p=0.003). Patients with VA worse than 20/200 had an odds ratio of 2.89 for PVR development (p<0.001).
CONCLUSIONS: Patients with a history RRD with PVR in one eye, have approximately 3.5 times higher rate of PVR in their second eye after RRD compared with patients without a history of PVR. This finding potential impacts surgical decisions and use of prophylactic anti-PVR therapy if the patient\'s second eye has RRD. The final visual acuity in second eye of patients with history PVR is better than for the second eye of patients with no history of PVR which may indicate surgeons are already taking steps to prevent PVR in the patient\'s second eye.
摘要：
目的：研究增生性玻璃体视网膜病变（PVR）的发生率和危险因素，这些患者曾发生过视网膜脱离（RRD）并伴有PVR。
方法：多中心，回顾性观察性研究。
方法：通过Vestrum健康数据库方法：PVR发展的危险因素，确定了2015年至2023年之间视网膜脱离和PVR的眼睛，在同伴眼中特别记录了PVR，性别,年龄,镜头状态,呈现和最终的视力，进行了评估。
方法：术后6个月PVR发展的几率。
结果：在57,264例患者中，11%的人至少一只眼睛有PVR。在初次RRD后未发生PVR的50,989例患者中，4,834在同伴眼中发展了RRD。这些患者中的166人在他们的第二只眼睛中发生了PVR，在另一只眼睛中的PVR率为3％。在原发性RRD修复后发生PVR的6,275例患者中，这些患者中的406人继续在他们的眼睛中发展RRD。这些患者中的42例第二眼发生PVR,PVR率为10%。回归模型还包括年龄，性别和视力的比值比为3.42（p<0.001）。PVR发展的比值比普遍随年龄的增长而下降。假晶状体患者的PVR发展优势比较高，1.48（p=0.017）。初始VA20/40-20/80患者的比值比为2.15（p=0.003）。VA低于20/200的患者PVR发展的比值比为2.89（p<0.001）。
结论：有一只眼PVR病史的患者，与没有PVR病史的患者相比，RRD后第二眼的PVR发生率约为3.5倍。如果患者的第二只眼睛有RRD，这一发现可能会影响手术决策和预防性抗PVR治疗的使用。有PVR病史的患者的第二只眼的最终视力优于没有PVR病史的患者的第二只眼，这可能表明外科医生已经采取措施防止患者的第二只眼发生PVR。
方法：多中心，回顾性观察性研究。
方法：通过Vestrum健康数据库方法：PVR发展的危险因素，确定了2015年至2023年之间视网膜脱离和PVR的眼睛，在同伴眼中特别记录了PVR，性别,年龄,镜头状态,呈现和最终的视力，进行了评估。
方法：术后6个月PVR发展的几率。
结果：在57,264例患者中，11%的人至少一只眼睛有PVR。在初次RRD后未发生PVR的50,989例患者中，4,834在同伴眼中发展了RRD。这些患者中的166人在他们的第二只眼睛中发生了PVR，在另一只眼睛中的PVR率为3％。在原发性RRD修复后发生PVR的6,275例患者中，这些患者中的406人继续在他们的眼睛中发展RRD。这些患者中的42例第二眼发生PVR,PVR率为10%。回归模型还包括年龄，性别和视力的比值比为3.42（p<0.001）。PVR发展的比值比普遍随年龄的增长而下降。假晶状体患者的PVR发展优势比较高，1.48（p=0.017）。初始VA20/40-20/80患者的比值比为2.15（p=0.003）。VA低于20/200的患者PVR发展的比值比为2.89（p<0.001）。
结论：有一只眼PVR病史的患者，与没有PVR病史的患者相比，RRD后第二眼的PVR发生率约为3.5倍。如果患者的第二只眼睛有RRD，这一发现可能会影响手术决策和预防性抗PVR治疗的使用。有PVR病史的患者的第二只眼的最终视力优于没有PVR病史的患者的第二只眼，这可能表明外科医生已经采取措施防止患者的第二只眼发生PVR。
