Mesh : Pyroptosis Lipoylation Humans Animals Phosphate-Binding Proteins / metabolism genetics Intracellular Signaling Peptides and Proteins / metabolism genetics Cell Membrane / metabolism Cysteine / metabolism Protein Transport Gasdermins

来  源:   DOI:10.1016/j.molcel.2024.05.023

Abstract:
Three recent publications by Du et al.,1 Balasubramanian et al.,2 and Zhang et al.3 identified palmitoylation on cysteine 191/192 in gasdermin D as a key determinant of gasdermin D membrane translocation and oligomerization, ensuring efficient plasma membrane permeabilization during pyroptosis.
摘要:
Du等人最近发表的三篇文章。,1Balasubramanian等人。,2和Zhang等3确定gasderminD中半胱氨酸191/192的棕榈酰化是gasderminD膜易位和寡聚化的关键决定因素,确保焦亡过程中有效的质膜透化。
公众号