Abstract：
Parasitic co-infections are common in developing countries and can interfere with leprosy treatment, leading to an increased risk of inflammatory leprosy reactions. This study assessed serum immunoglobulin G (IgG) levels against Toxoplasma gondii and Visceral Leishmaniasis (VL) antigens in 270 leprosy patients from Brazilian states. Regarding the respective cut-offs, the prevalence of IgG seropositivity for T. gondii and VL were 21.05 % and 47.36 % in the leprosy-negative group, and 77.7 % and 52.6 % in the leprosy-positive group. Of the 270 leprosy patients, 158 (58.5 %) presented with inflammatory leprosy reactions. Of those, 72 (59.5 %) had neuritis, 35 (48.6 %) had reverse reactions, and 28 (38.9 %) had ENL in both Brazilian states. Leprosy patients with anti-Leishmania IgG seropositivity were 3.25 times more likely to develop neuritis (95 % C.I.: 1.187 - 9.154; p = 0.019). These findings are particularly relevant for clinical settings where both leprosy and parasitic diseases are prevalent and could provide essential guidance for detecting and addressing complications arising from parasitic co-infections in leprosy patients, thereby improving clinical management strategies.
摘要：
寄生虫共同感染在发展中国家很常见，会干扰麻风治疗，导致炎性麻风反应的风险增加。这项研究评估了来自巴西各州的270名麻风病患者的血清免疫球蛋白G（IgG）针对弓形虫和内脏利什曼病（VL）抗原的水平。关于各自的截止日期，麻风阴性组弓形虫和VL的IgG阳性患病率分别为21.05％和47.36％，麻风病阳性组分别为77.7%和52.6%。270名麻风病人中,158例（58.5%）出现炎性麻风反应。其中,72（59.5%）有神经炎，35例（48.6%）有逆反应，和28（38.9%）有ENL在巴西两个州。具有抗利什曼原虫IgG血清阳性的麻风病患者发生神经炎的可能性是3.25倍（95％C.I.：1.187-9.154；p=0.019）。这些发现与麻风病和寄生虫病流行的临床环境特别相关，可以为检测和解决麻风病患者寄生虫共感染引起的并发症提供必要的指导。从而改进临床管理策略。
