Abstract：
Exfoliation syndrome and exfoliation glaucoma comprise a unique age-related ocular aggregopathy characterized by the accumulation of protein complex aggregates in different ocular structures. Recent literature and studies have expanded our knowledge of the clinical characteristic features, phenotypical variations, and molecular pathophysiology associated with disease onset or development of glaucoma. Despite years of studies on the various epidemiological, clinical, and molecular facets of the disease, the exact mechanism of disease onset, formation of aggregates, and the events that trigger the development of glaucoma marking irreversibility in the disease remains elusive. This review elaborates on the existing and new insights that we have gained over the years and highlights gaps in the knowledge about the disease that need future exploration.
摘要：
剥脱综合征和剥脱性青光眼包括独特的年龄相关的眼部聚集病,其特征在于蛋白质复合物聚集体在不同的眼部结构中的积累。最近的文献和研究扩大了我们对临床特征特征的认识，表型变异，与青光眼发病或发展相关的分子病理生理学。尽管对各种流行病学进行了多年的研究，临床,和疾病的分子层面，疾病发作的确切机制，聚集体的形成，在疾病中引发青光眼标记不可逆性的事件仍然难以捉摸。这篇综述详细阐述了我们多年来获得的现有和新见解，并强调了需要未来探索的关于该疾病的知识差距。
