Abstract：
Huntington\'s disease (HD) is an autosomal dominant disorder that affects the basal ganglia, caused by CAG repeats in the huntingtin gene. Delusional infestation (DI) is a rare psychotic manifestation of the disease. This report presents two cases of HD patients with DI, both middle-aged females. The first patient achieved remission of DI with olanzapine, later cross-tapered to risperidone, but had spontaneous relapses. The second experienced gradual resolution of DI with risperidone in the setting of iron repletion and amantadine discontinuation, although her other psychotic symptoms remained. These cases shed light on an uncommon condition and may help guide understanding of the most effective treatment for it.
摘要：
亨廷顿病（HD）是一种影响基底神经节的常染色体显性疾病，由亨廷顿基因中的CAG重复引起。妄想侵染（DI）是该疾病的罕见精神病表现。本报告介绍了2例伴有DI的HD患者，都是中年女性。第一例患者使用奥氮平实现DI缓解，后来交叉锥形到利培酮，但有自发性复发.在铁补充和金刚烷胺停药的情况下，第二个经历了DI与利培酮的逐渐消退，尽管她的其他精神病症状仍然存在。这些病例揭示了一种罕见的情况，可能有助于指导人们对最有效的治疗方法的理解。
