Abstract：
UNASSIGNED: Low back pain and sciatica caused by herniated lumbar discs (HLDs) are common complaints among patients visiting pain clinics. Among the various therapeutic methods, intradiscal ozone injections have emerged as an effective alternative or additional treatment option for HLDs.
UNASSIGNED: This meta-analysis aimed to investigate the effectiveness of intradiscal ozone injections in the treatment of HLDs.
UNASSIGNED: We searched the PubMed, Embase, Cochrane Library, and Scopus databases for relevant studies published until January 25, 2024. We included studies that investigated the efficacy of intradiscal ozone injections in patients with HLDs. We evaluated the methodological quality of individual studies using the Cochrane Collaboration tool.
UNASSIGNED: At ⩾ 6 months after treatment, the therapeutic effect of intradiscal ozone injections in patients with HLDs was greater than that of steroid injections (treatment success rate, 6 months: odds ratio = 3.95, 95% confidence interval [CI] [2.44, 6.39], P< 0.01) or conventional medications (changes in the Visual Analog Scale [VAS], 6 months: standardized mean difference [SMD] = 1.65, 95% CI [1.08, 2.22], P< 0.01; 12 months: SMD = 1.52, 95% CI [0.96, 2.08], P< 0.01) but similar to that of microdiscectomy (changes in VAS, 18 months: SMD =-0.05, 95% CI [-0.67, 0.57], P= 0.87). At < 6 months after treatment, the reduction in the VAS score after intradiscal ozone injections was higher than that after steroid injections (changes in VAS, 1 month: SMD = 2.53, 95% CI [1.84, 3.21], P< 0.01).
UNASSIGNED: Intradiscal ozone injections may be a useful therapeutic tool in patients with HLDs. Compared with other conventional treatment methods such as steroid injections and oral medications, intradiscal ozone injection has great long-term (⩾ 6 months) effectiveness.
UNASSIGNED: This meta-analysis aimed to investigate the effectiveness of intradiscal ozone injections in the treatment of HLDs.
UNASSIGNED: We searched the PubMed, Embase, Cochrane Library, and Scopus databases for relevant studies published until January 25, 2024. We included studies that investigated the efficacy of intradiscal ozone injections in patients with HLDs. We evaluated the methodological quality of individual studies using the Cochrane Collaboration tool.
UNASSIGNED: At ⩾ 6 months after treatment, the therapeutic effect of intradiscal ozone injections in patients with HLDs was greater than that of steroid injections (treatment success rate, 6 months: odds ratio = 3.95, 95% confidence interval [CI] [2.44, 6.39], P< 0.01) or conventional medications (changes in the Visual Analog Scale [VAS], 6 months: standardized mean difference [SMD] = 1.65, 95% CI [1.08, 2.22], P< 0.01; 12 months: SMD = 1.52, 95% CI [0.96, 2.08], P< 0.01) but similar to that of microdiscectomy (changes in VAS, 18 months: SMD =-0.05, 95% CI [-0.67, 0.57], P= 0.87). At < 6 months after treatment, the reduction in the VAS score after intradiscal ozone injections was higher than that after steroid injections (changes in VAS, 1 month: SMD = 2.53, 95% CI [1.84, 3.21], P< 0.01).
UNASSIGNED: Intradiscal ozone injections may be a useful therapeutic tool in patients with HLDs. Compared with other conventional treatment methods such as steroid injections and oral medications, intradiscal ozone injection has great long-term (⩾ 6 months) effectiveness.
摘要：
■腰椎间盘突出症（HLDs）引起的下腰痛和坐骨神经痛是就诊于疼痛诊所的患者常见的主诉。在各种治疗方法中，盘内臭氧注射已成为HLDs的有效替代或额外治疗选择。
■这项荟萃分析旨在研究椎间盘内注射臭氧治疗HLDs的有效性。
■我们搜索了PubMed，Embase,科克伦图书馆,以及截至2024年1月25日发表的相关研究的Scopus数据库。我们纳入了研究盘内臭氧注射对HLDs患者的疗效的研究。我们使用Cochrane协作工具评估了各个研究的方法学质量。
■治疗后6个月，对患有HLDs的患者进行盘内臭氧注射的治疗效果大于类固醇注射的治疗效果(治疗成功率，6个月：比值比=3.95，95%置信区间[CI][2.44，6.39]，P<0.01）或常规药物（视觉模拟量表[VAS]的变化，6个月：标准化平均差[SMD]=1.65，95%CI[1.08，2.22]，P<0.01；12个月：SMD=1.52，95%CI[0.96，2.08]，P<0.01），但与显微椎间盘切除术相似（VAS的变化，18个月：SMD=-0.05，95%CI[-0.67，0.57]，P=0.87）。治疗后<6个月，盘内臭氧注射后VAS评分的降低高于类固醇注射后（VAS的变化，1个月：SMD=2.53，95%CI[1.84，3.21]，P<0.01)。
■盘内臭氧注射可能是HLDs患者的有用治疗工具。与类固醇注射和口服药物等其他常规治疗方法相比，盘内臭氧注射有很大的长期（6个月）的有效性。
■这项荟萃分析旨在研究椎间盘内注射臭氧治疗HLDs的有效性。
■我们搜索了PubMed，Embase,科克伦图书馆,以及截至2024年1月25日发表的相关研究的Scopus数据库。我们纳入了研究盘内臭氧注射对HLDs患者的疗效的研究。我们使用Cochrane协作工具评估了各个研究的方法学质量。
■治疗后6个月，对患有HLDs的患者进行盘内臭氧注射的治疗效果大于类固醇注射的治疗效果(治疗成功率，6个月：比值比=3.95，95%置信区间[CI][2.44，6.39]，P<0.01）或常规药物（视觉模拟量表[VAS]的变化，6个月：标准化平均差[SMD]=1.65，95%CI[1.08，2.22]，P<0.01；12个月：SMD=1.52，95%CI[0.96，2.08]，P<0.01），但与显微椎间盘切除术相似（VAS的变化，18个月：SMD=-0.05，95%CI[-0.67，0.57]，P=0.87）。治疗后<6个月，盘内臭氧注射后VAS评分的降低高于类固醇注射后（VAS的变化，1个月：SMD=2.53，95%CI[1.84，3.21]，P<0.01)。
■盘内臭氧注射可能是HLDs患者的有用治疗工具。与类固醇注射和口服药物等其他常规治疗方法相比，盘内臭氧注射有很大的长期（6个月）的有效性。
