Abstract：
OBJECTIVE: The human commensal microbiota is now widely accepted as a key regulator of human health and disease. The composition of the mucosal associated microbiota has been shown to play a critical role in the lung health. The role of the mucosal microbiota in the development and severity of allergy, asthma, and occupational lung disease is only beginning to take shape. However, advances in our understanding of these links have tremendous potential to led to new clinical interventions to reduce allergy, asthma, and occupational lung disease morbidity.
RESULTS: We review recent work describing the relationship and role of the commensal microbiota in the development of allergy, asthma, and occupational lung disease. Our review primarily focuses on occupational exposures and the effects of the microbiome, both in composition and function. Data generated from these studies may lead to the development of interventions targeted at establishing and maintaining a healthy microbiota. We also highlight the role of environmental exposures and the effects on the commensal microbial community and their potential association with occupational lung disease. This review explores the current research describing the role of the human microbiome in the regulation of pulmonary health and disease, with a specific focus on the role of the mucosal microbiota in the development of allergy, asthma, and occupational lung disease.
RESULTS: We review recent work describing the relationship and role of the commensal microbiota in the development of allergy, asthma, and occupational lung disease. Our review primarily focuses on occupational exposures and the effects of the microbiome, both in composition and function. Data generated from these studies may lead to the development of interventions targeted at establishing and maintaining a healthy microbiota. We also highlight the role of environmental exposures and the effects on the commensal microbial community and their potential association with occupational lung disease. This review explores the current research describing the role of the human microbiome in the regulation of pulmonary health and disease, with a specific focus on the role of the mucosal microbiota in the development of allergy, asthma, and occupational lung disease.
摘要：
目的：人类共生菌群现在被广泛接受为人类健康和疾病的关键调节因子。粘膜相关微生物群的组成已被证明在肺部健康中起关键作用。粘膜微生物在变态反应的发展和严重程度中的作用，哮喘,职业性肺病才刚刚开始形成。然而,我们对这些联系的理解的进步具有巨大的潜力，可以导致新的临床干预措施来减少过敏，哮喘,和职业性肺病发病率。
结果：我们回顾了描述共生微生物群在变态反应发展中的关系和作用的最新工作，哮喘,和职业性肺病。我们的审查主要集中在职业暴露和微生物组的影响，在组成和功能上。这些研究产生的数据可能导致旨在建立和维持健康微生物群的干预措施的发展。我们还强调了环境暴露的作用，对共生微生物群落的影响及其与职业性肺病的潜在关联。这篇综述探讨了目前描述人类微生物组在调节肺部健康和疾病中的作用的研究，特别关注粘膜微生物群在过敏发展中的作用，哮喘,和职业性肺病。
结果：我们回顾了描述共生微生物群在变态反应发展中的关系和作用的最新工作，哮喘,和职业性肺病。我们的审查主要集中在职业暴露和微生物组的影响，在组成和功能上。这些研究产生的数据可能导致旨在建立和维持健康微生物群的干预措施的发展。我们还强调了环境暴露的作用，对共生微生物群落的影响及其与职业性肺病的潜在关联。这篇综述探讨了目前描述人类微生物组在调节肺部健康和疾病中的作用的研究，特别关注粘膜微生物群在过敏发展中的作用，哮喘,和职业性肺病。
