Abstract：
High doses of ionizing radiation are the risk factor of cognitive dysfunction and anxiety disorders developing in humans and experimental animals. However, the data on the effect of low doses, especially in case of chronic or fractionated exposure, is limited and contradictory. Here we studied the effect of fractionated γ-radiation at cumulative doses of 0.1, 1, and 5 Gy on the parameters of the anxiety-like behavior in neonatal C57BL/6 mice. The anxiety was evaluated using the marble burying test and elevated plus maze. Fractionated irradiation resulted in dose-dependent changes in mouse behavior: the low dose caused an increase in anxiety, wherein the dose raise led to the decrease in anxiety-like behavior indicators compared to non-irradiated animals.
摘要：
高剂量的电离辐射是人类和实验动物发生认知功能障碍和焦虑症的危险因素。然而,低剂量效果的数据，尤其是在慢性或分段暴露的情况下，是有限的和矛盾的。在这里，我们研究了累积剂量为0.1、1和5Gy的分级γ辐射对新生C57BL/6小鼠焦虑样行为参数的影响。使用大理石掩埋测试和高架迷宫评估焦虑。分级照射导致小鼠行为的剂量依赖性变化：低剂量导致焦虑增加，其中与未照射的动物相比,剂量增加导致焦虑样行为指标的降低。
