能量应激介导的 AMPK 激活对三阴性乳腺癌中的 MPS1 激酶抑制敏感。
关键词: AMPK MPS1 kinase TNBC TTK protein kinase breast cancer energy stress
Mesh : Triple Negative Breast Neoplasms / drug therapy pathology metabolism Humans Female Animals Mice Aminoimidazole Carboxamide / analogs & derivatives pharmacology AMP-Activated Protein Kinases / metabolism Xenograft Model Antitumor Assays Cell Line, Tumor Ribonucleotides / pharmacology Protein Serine-Threonine Kinases / metabolism antagonists & inhibitors Cell Cycle Proteins / metabolism antagonists & inhibitors genetics Apoptosis / drug effects Autophagy / drug effects Protein-Tyrosine Kinases / metabolism antagonists & inhibitors Protein Kinase Inhibitors / pharmacology therapeutic use Cell Proliferation / drug effects Signal Transduction / drug effects Drug Synergism Biphenyl Compounds Pyrones Thiophenes
来 源:
DOI:10.3892/or.2024.8760
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