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Abstract：
CD44 genetic variants have been found to be related to various cancers. However, to date, no study has demonstrated the involvement of CD44 polymorphisms in uterine cervical cancer in Taiwanese women. Therefore, we conducted a retrospective study, consecutively recruiting 113 patients with invasive cancer, 92 patients with high-grade cervical intraepithelial neoplasias, and 302 control women to assess the relationships among CD44 polymorphisms, cervical carcinogenesis, and patient survival. Real-time polymerase chain reaction was used to determine the genotypic distributions of six polymorphisms: rs1425802, rs187115, rs713330, rs11821102, rs10836347, and rs13347. The results revealed that women with the mutant homozygous genotype CC exhibited a higher risk of invasive cancer compared to those with the wild homozygous genotype TT [p=0.035; hazard ratio (HR)=10.29, 95% confidence interval (95% CI)=1.18-89.40] and TT/TC [p=0.032; HR=10.66, 95% CI=1.23-92.11] in the CD44 polymorphism rs713330. No significant association was found between CD44 genetic variants and clinicopathological parameters. Among the clinicopathological parameters, only positive pelvic lymph node metastasis (p=0.002; HR=8.57, 95% CI=2.14-34.38) and the AG/GG genotype compared to AA (p=0.014; HR=3.30, 95% CI=1.28-8.49) in CD44 polymorphism rs187115 predicted a higher risk of poor five-year survival, according to multivariate analysis. In conclusion, an important and novel finding revealed that Taiwanese women with the AG/GG genotype in CD44 polymorphism rs187115 exhibited a higher risk of poor five-year survival.
摘要：
已经发现CD44遗传变异与各种癌症有关。然而,到目前为止,尚无研究证明CD44多态性与台湾女性子宫颈癌有关.因此,我们进行了一项回顾性研究,连续招募113名浸润性癌症患者，92例宫颈高级别上皮内瘤变，和302名对照妇女评估CD44多态性之间的关系，宫颈癌发生，和病人的生存。实时聚合酶链反应用于确定六个多态性的基因型分布：rs1425802，rs187115，rs713330，rs11821102，rs10836347和rs13347。结果显示，在CD13rs7330多态性中，突变纯合基因型CC的女性患浸润性癌的风险高于野生纯合基因型TT的女性[p=0.035；风险比（HR）=10.29，95％置信区间（95％CI）=1.18-89.40]和TT/TC[p=0.032；HR=10.66，95％CI=1.23-92.11]。在CD44遗传变异与临床病理参数之间没有发现显着关联。在临床病理参数中，仅盆腔淋巴结转移阳性（p=0.002;HR=8.57，95％CI=2.14-34.38）和AG/GG基因型与AA相比（p=0.014;HR=3.30，95％CI=1.28-8.49）在CD44多态性rs187115中预测五年生存率低的风险较高，根据多变量分析。总之,一项重要而新颖的发现表明，在CD44多态性rs187115中具有AG/GG基因型的台湾女性表现出更高的五年生存率。
