PDF(Pubmed)
Abstract：
UNASSIGNED: The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS).
UNASSIGNED: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI.
UNASSIGNED: Patients expressed significantly higher An-V (5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL, p<0.001) and IL-13 (19.2 ± 7.6 vs. 3.4 ± 1.4 ng/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 ± 0.06 vs. 0.35 ± 0.03, p<0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters.
UNASSIGNED: The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13.
UNASSIGNED: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI.
UNASSIGNED: Patients expressed significantly higher An-V (5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL, p<0.001) and IL-13 (19.2 ± 7.6 vs. 3.4 ± 1.4 ng/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 ± 0.06 vs. 0.35 ± 0.03, p<0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters.
UNASSIGNED: The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13.
摘要：
■当前研究的目的是评估颈动脉内中膜厚度（CIMT）测量值之间的关系，特发性肾病综合征（INS）患儿的肾脏多普勒阻力指数（RI）和血清白细胞介素13（IL-13）和膜联蛋白V（An-V）水平。
■本病例对照研究是对60名患有INS的儿童和60名年龄和性别匹配的健康儿童进行的。所有参与者均接受了IL-13和An-V的血清水平评估以及CIMT和肾脏RI的超声多普勒测量。
■患者表达An-V显着升高（5.9±2.6vs.2.1±0.8ng/mL，p<0.001）和IL-13（19.2±7.6vs.与健康同行相比，3.4±1.4ng/L）水平。此外，结果表明，患者的MT显著较高的CI(0.49±0.06vs.0.35±0.03，p<0.001）与对照组相比。在右侧或左侧RI方面，研究组之间没有发现显着差异。相关性分析确定血清An-V水平与白蛋白/肌酐比值（ACR）之间存在显著的直接相关性（r=0.55），胆固醇（r=0.48），甘油三酯（r=0.36），IL-13(r=0.92)和CIMT(r=0.53)。在血清IL-13水平和CIMT测量值与相应参数之间可以发现类似的相关性。
■本研究表明，在INS患儿中，以升高的CIMT测量值表示的早期动脉粥样硬化与血清An-V和IL-13升高之间存在关联。
■本病例对照研究是对60名患有INS的儿童和60名年龄和性别匹配的健康儿童进行的。所有参与者均接受了IL-13和An-V的血清水平评估以及CIMT和肾脏RI的超声多普勒测量。
■患者表达An-V显着升高（5.9±2.6vs.2.1±0.8ng/mL，p<0.001）和IL-13（19.2±7.6vs.与健康同行相比，3.4±1.4ng/L）水平。此外，结果表明，患者的MT显著较高的CI(0.49±0.06vs.0.35±0.03，p<0.001）与对照组相比。在右侧或左侧RI方面，研究组之间没有发现显着差异。相关性分析确定血清An-V水平与白蛋白/肌酐比值（ACR）之间存在显著的直接相关性（r=0.55），胆固醇（r=0.48），甘油三酯（r=0.36），IL-13(r=0.92)和CIMT(r=0.53)。在血清IL-13水平和CIMT测量值与相应参数之间可以发现类似的相关性。
■本研究表明，在INS患儿中，以升高的CIMT测量值表示的早期动脉粥样硬化与血清An-V和IL-13升高之间存在关联。
