PDF(Pubmed)
Abstract：
Type 1 diabetes mellitus (T1DM) is a metabolic disorder characterized by an absolute deficiency of insulin due to pancreatic failure. Diabetes ketoacidosis (DKA) has emerged as one of the most common complications of T1DM. Although exceedingly rare, the onset of T1DM with DKA may result in lipemia secondary to severe hypertriglyceridemia (HTG), accounting for several cases in the pediatric population. Along this line, plasma exchange treatment in children with DKA and severe hyperlipidemia has only been reported in some cases. In this case report, the diagnosis of an 11-year-old girl with diabetes ketoacidosis accompanied by severe HTG, along with subsequent plasma exchange treatment, is presented. Initially, the patient received initial management with crystalloid fluid bolus and intravenous insulin therapy. Despite rapid correction of acidosis, persistent HTG subsequently prompted the plasma exchange treatment. A total of three sessions were administered over 2 days, leading to a significant reduction in the triglyceride levels and corneal opacity resolution, indicating a successful therapeutic intervention.
摘要：
1型糖尿病（T1DM）是一种代谢紊乱，其特征是由于胰腺功能衰竭而导致的胰岛素绝对缺乏。糖尿病酮症酸中毒（DKA）已成为T1DM最常见的并发症之一。虽然非常罕见，T1DM伴DKA的发作可能导致严重高甘油三酯血症（HTG）继发的血脂，占儿科人群的几例。沿着这条线,仅在某些病例中报道了DKA和重度高脂血症患儿的血浆置换治疗.在这个案例报告中,诊断为患有糖尿病酮症酸中毒并伴有严重HTG的11岁女孩，随着随后的血浆置换治疗，是presented。最初，患者接受了晶体液体推注和静脉胰岛素治疗的初始管理.尽管酸中毒得到了迅速纠正,持续性HTG随后提示血浆置换治疗.共进行了3次疗程,为期2天,导致甘油三酯水平和角膜混浊分辨率显着降低，表明成功的治疗干预。
