PDF(Pubmed)
Abstract：
Orf is a zoonosis caused by the Orf virus (ORFV), which is endemic in goats, sheep, and wild ruminants worldwide. Orf infection is prevalent in China, with outbreaks reported in several provinces. Currently, there is limited information available regarding the characterization of ORFV strains in Jiangxi province. This study investigated an acute outbreak of Orf that occurred in 2021 in a goat herd in the Jiangxi province of China. Clinical signs in this case included lesions on the lips, nose, and inside the mouth. The presence of ORFV was confirmed from tissue samples by polymerase chain reaction (PCR). The nucleotide sequences of the B2L and F1L genes were fully sequenced and used to construct phylogenetic trees. The results of this investigation identified the ORFV JXxy2021 as the cause of the outbreak. The phylogenetic analysis revealed that the ORFV strain JXxy2021 had the highest similarity to the ORFV strains GO and FJ-SL from the neighboring province of Fujian. This suggests that JXxy2021 was likely transmitted from Fujian province. The results have provided valuable information on the genetic characteristics of JXxy2021 and the endemic situations of Orf in China.
摘要：
Orf是由Orf病毒（ORFV）引起的人畜共患病，这是山羊特有的，绵羊,和全世界的野生反刍动物。Orf感染在中国很普遍,据报道，几个省份爆发了疫情。目前,关于江西省ORFV毒株特性的信息有限。这项研究调查了2021年在中国江西省的羊群中发生的Orf急性爆发。这种情况下的临床症状包括嘴唇上的病变，鼻子,在嘴里。通过聚合酶链反应(PCR)从组织样品中确认ORFV的存在。对B2L和F1L基因的核苷酸序列进行了完整测序，并用于构建系统发育树。这项调查的结果确定了ORFVJXxy2021是爆发的原因。系统发育分析表明，ORFV菌株JXxy2021与邻近福建省的ORFV菌株GO和FJ-SL具有最高的相似性。这表明JXxy2021可能是从福建省传播的。研究结果为JXxy2021的遗传特征和中国Orf的流行情况提供了有价值的信息。
