PDF(Pubmed)
Abstract：
UNASSIGNED: This article explores the association between fractures, particularly in the elderly, and elevated plasma high-density lipoprotein cholesterol (HDL-C) levels. The study challenges the conventional idea of HDL-C as \"good cholesterol\" by revealing its potential role as a risk factor for fractures. Factors contributing to fractures in the elderly, such as diminishing bone strength due to aging-related tissue breakdown, are discussed. Sedentary lifestyles, low bone mineral density (BMD), and habits like smoking and alcohol consumption compound fracture susceptibility.
UNASSIGNED: The study delves into mechanisms linking elevated HDL-C to fractures, using data from the ASPREE-Fracturesub-study of the ASPREE trial involving Australian and American participants aged 65 and above.
UNASSIGNED: The study showed that over a 4-year period, elevated HDL-C levels in healthy older people were linked to a 14% higher fracture risk. This revelation expands the understanding of fracture risk factors beyond the established norms.
UNASSIGNED: The article emphasizes the need to reconsider HDL-C\'s traditional role as an indicator of cardiovascular health, particularly in light of medications like Statins and Anacetrapib that raise HDL-C levels. It calls for further exploration into the relationship between HDL-C, fractures at varying sites, and different age groups. Practical implications involve incorporating fracture risk associated with high HDL-C into clinical considerations, alongside advocating lifestyle changes for optimal HDL-C levels. In summary, this study prompts a reevaluation of HDL-C\'s implications in clinical practice, demanding further investigation into the intricacies of this relationship.
UNASSIGNED: The study delves into mechanisms linking elevated HDL-C to fractures, using data from the ASPREE-Fracturesub-study of the ASPREE trial involving Australian and American participants aged 65 and above.
UNASSIGNED: The study showed that over a 4-year period, elevated HDL-C levels in healthy older people were linked to a 14% higher fracture risk. This revelation expands the understanding of fracture risk factors beyond the established norms.
UNASSIGNED: The article emphasizes the need to reconsider HDL-C\'s traditional role as an indicator of cardiovascular health, particularly in light of medications like Statins and Anacetrapib that raise HDL-C levels. It calls for further exploration into the relationship between HDL-C, fractures at varying sites, and different age groups. Practical implications involve incorporating fracture risk associated with high HDL-C into clinical considerations, alongside advocating lifestyle changes for optimal HDL-C levels. In summary, this study prompts a reevaluation of HDL-C\'s implications in clinical practice, demanding further investigation into the intricacies of this relationship.
摘要：
■本文探讨了骨折之间的关联，尤其是老年人，血浆高密度脂蛋白胆固醇（HDL-C）水平升高。该研究通过揭示HDL-C作为骨折危险因素的潜在作用，挑战了HDL-C作为“好胆固醇”的传统观念。导致老年人骨折的因素，例如由于与衰老相关的组织破裂而导致的骨强度降低，正在讨论。久坐的生活方式，低骨密度（BMD），和吸烟和饮酒等习惯复合骨折易感性。
■该研究深入研究了HDL-C升高与骨折的联系机制，使用ASPREE-Fracturesub研究的数据,该研究涉及65岁及以上的澳大利亚和美国参与者.
■研究表明，在4年的时间里，健康老年人HDL-C水平升高与骨折风险增加14%相关.这一启示扩展了对骨折危险因素的理解，超出了既定的规范。
■文章强调需要重新考虑HDL-C作为心血管健康指标的传统作用，特别是考虑到他汀类药物和Anacetrapib等药物可以提高HDL-C水平。它要求进一步探索HDL-C之间的关系，不同部位的骨折,和不同的年龄组。实际意义涉及将高HDL-C相关的骨折风险纳入临床考虑。同时提倡改变生活方式以获得最佳HDL-C水平。总之,这项研究促使重新评估HDL-C在临床实践中的意义，要求进一步调查这种关系的复杂性。
■该研究深入研究了HDL-C升高与骨折的联系机制，使用ASPREE-Fracturesub研究的数据,该研究涉及65岁及以上的澳大利亚和美国参与者.
■研究表明，在4年的时间里，健康老年人HDL-C水平升高与骨折风险增加14%相关.这一启示扩展了对骨折危险因素的理解，超出了既定的规范。
■文章强调需要重新考虑HDL-C作为心血管健康指标的传统作用，特别是考虑到他汀类药物和Anacetrapib等药物可以提高HDL-C水平。它要求进一步探索HDL-C之间的关系，不同部位的骨折,和不同的年龄组。实际意义涉及将高HDL-C相关的骨折风险纳入临床考虑。同时提倡改变生活方式以获得最佳HDL-C水平。总之,这项研究促使重新评估HDL-C在临床实践中的意义，要求进一步调查这种关系的复杂性。
