PDF(Pubmed)
Abstract：
There have rarely been reports on the neoplastic transformation in other organs during immunotherapy for lung cancer. We report the case of a 71-year-old man who was diagnosed with advanced pulmonary adenocarcinoma and a thyroid tumor. The patient responded to chemoradiotherapy but developed a recurrence of pulmonary metastasis. Therefore, nivolumab was started, and a complete response for pulmonary metastasis was achieved. After 32 nivolumab cycles, he experienced neck pain, and the thyroid tumor grew rapidly. Histological examination revealed anaplastic thyroid carcinoma. Although rare, immunotherapy for lung cancer has the potential to induce neoplastic transformation in other organs.
摘要：
很少有关于肺癌免疫治疗过程中其他器官肿瘤转化的报道。我们报告了一名71岁的男子，他被诊断患有晚期肺腺癌和甲状腺肿瘤。患者对放化疗有反应，但复发了肺转移。因此,Nivolumab开始了,肺转移完全缓解。在32个nivolumab周期后，他经历了颈部疼痛,甲状腺肿瘤迅速发展。组织学检查显示甲状腺未分化癌。虽然罕见，肺癌的免疫治疗有可能诱导其他器官的肿瘤转化。
