PDF(Pubmed)
Abstract：
COVID-19 is a viral disease that can manifest acutely in the respiratory tract and other organs. In this study, we aimed to investigate potential long-term damage to the heart from COVID-19. For this study, we divided 97 consecutive unselected COVID-19 patients aged 18-80 years at a cardiology practice in Cologne, Germany, into two groups based on the severity of their infection. We performed a resting ECG and a resting transthoracic echocardiography three and six months after SARS-CoV2 infection. The key discriminator determining disease severity was bed confinement or hospital admission. Group 1 included patients with less severe COVID-19, whereas group 2 contained more severe cases. Heart rate as the primary ECG endpoint was lower by a statistically significant amount for the entire study population (p=0.024), subdivided by gender (pwomen <0.001, pmen <0.001) and in group 1 p =0.003 compared to three months. QTc time and repolarization disturbances as primary ECG endpoints and the echocardiographic primary endpoints, left ventricular ejection fraction, and left ventricular end-diastolic diameter (LVEDD), showed no relevant difference between the subgroups at three and six months or between the measurements taken at each point. In contrast, LVEDD normalized to body surface area was statistically significantly lower at six months in women in group 1 compared to group 2 (p=0.048) and in the overall study population at six months compared with the data after three months (p=0.034). E/E\' was statistically lower at six months than at three months in the whole population (p=0.004) and in women (p=0.031). All measured echocardiographic and electrocardiographic mean values were within the normal range in all groups and follow-up controls. Overall, the prospective study conducted showed no significant evidence of long-term cardiac damage from COVID-19 disease, as evidenced by electrocardiographic and echocardiographic examinations at three and six months after infection.
摘要：
COVID-19是一种病毒性疾病，可在呼吸道和其他器官中急剧表现。在这项研究中,我们的目的是调查COVID-19对心脏的潜在长期损害。对于这项研究，我们在科隆的心脏病学诊所中连续抽取了97例18-80岁的未选择的COVID-19患者，德国,根据感染的严重程度分为两组。SARS-CoV2感染后三个月和六个月，我们进行了静息心电图和静息经胸超声心动图检查。决定疾病严重程度的关键判别因素是卧床或入院。第1组包括不太严重的COVID-19患者，而第2组包括更严重的病例。在整个研究人群中，作为主要ECG终点的心率较低，具有统计学意义（p=0.024），按性别细分（pwomen<0.001，pmen<0.001），第1组与第3个月相比，p=0.003。QTc时间和复极紊乱作为主要ECG终点和超声心动图主要终点，左心室射血分数,和左心室舒张末期内径（LVEDD），在三个月和六个月的亚组之间或在每个点进行的测量之间没有相关差异。相比之下,与第2组相比，第1组女性在6个月时的LVEDD标准化为体表面积（p=0.048），并且与3个月后的数据（p=0.034）相比，在6个月时的总体研究人群中，LVEDD在统计学上显着降低。在整个人群（p=0.004）和女性（p=0.031）中，E/E'在六个月时在统计学上低于三个月时。在所有组和随访对照组中，所有测得的超声心动图和心电图平均值均在正常范围内。总的来说,进行的前瞻性研究显示，没有明显证据表明COVID-19疾病会造成长期心脏损害，感染后三个月和六个月的心电图和超声心动图检查证明了这一点。
