PDF(Pubmed)
Abstract：
Thiamine is an essential water-soluble vitamin that must be obtained through diet. This vitamin is crucial for various biochemical reactions and is vital for aerobic metabolism. When individuals are deficient in thiamine, which can be due to hypermetabolism (such as in inflammation, ischemia, or malnutrition, among other reasons), anaerobic metabolism may be utilized to maintain energy needs. Such chemical processes produce lactic acid. Excess lactic acid can cause various clinical signs and symptoms, though lactate dehydrogenase (LDH) can typically break down this compound. The following case presents a very unusual instance where a 51-year-old Caucasian woman presented with the chief complaint of ongoing and severe abdominal pain. After an extensive work-up ruling out numerous diagnoses and an eight-day hospital stay, it was believed that she may be suffering from hyperlactatemia secondary to thiamine deficiency, as she improved significantly after administration of this vitamin. It was thought that this was likely due to her previous systemic lupus erythematosus (SLE) diagnosis, vasculitis, chronic inflammation, and a hypermetabolic state, in addition to concurrent LDH malfunction.
摘要：
硫胺素是一种必需的水溶性维生素，必须通过饮食获得。这种维生素对各种生化反应至关重要，对有氧代谢至关重要。当个体缺乏硫胺素时，这可能是由于新陈代谢过度（例如在炎症中，缺血,或者营养不良，除其他原因外)，厌氧代谢可用于维持能量需求。这样的化学过程产生乳酸。过量的乳酸可引起各种临床体征和症状，尽管乳酸脱氢酶（LDH）通常可以分解该化合物。以下病例是一个非常不寻常的例子，一名51岁的白人妇女提出了持续和严重腹痛的主要投诉。经过广泛的检查，排除了许多诊断和八天的住院时间，据信她可能患有硫胺素缺乏症继发的高乳酸血症，服用这种维生素后，她的病情明显改善。人们认为这可能是由于她以前的系统性红斑狼疮（SLE）诊断，血管炎,慢性炎症，和高代谢状态，除了并发LDH故障。
