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Abstract：
Fundus neovascularization diseases are a series of blinding eye diseases that seriously impair vision worldwide. Currently, the means of treating these diseases in clinical practice are continuously evolving and have rapidly revolutionized treatment opinions. However, key issues such as inadequate treatment effectiveness, high rates of recurrence, and poor patient compliance still need to be urgently addressed. Multifunctional nanomedicine can specifically respond to both endogenous and exogenous microenvironments, effectively deliver drugs to specific targets and participate in activities such as biological imaging and the detection of small molecules. Nano-in-micro (NIM) delivery systems such as metal, metal oxide and up-conversion nanoparticles (NPs), quantum dots, and carbon materials, have shown certain advantages in overcoming the presence of physiological barriers within the eyeball and are widely used in the treatment of ophthalmic diseases. Few studies, however, have evaluated the efficacy of NIM delivery systems in treating fundus neovascular diseases (FNDs). The present study describes the main clinical treatment strategies and the adverse events associated with the treatment of FNDs with NIM delivery systems and summarizes the anatomical obstacles that must be overcome. In this review, we wish to highlight the principle of intraocular microenvironment normalization, aiming to provide a more rational approach for designing new NIM delivery systems to treat specific FNDs.
摘要：
眼底新生血管疾病是一系列严重损害视力的致盲眼病。目前,在临床实践中治疗这些疾病的手段在不断发展，并迅速彻底改变了治疗意见。然而,诸如治疗有效性不足等关键问题，高复发率,和不良的患者依从性仍然需要紧急解决。多功能纳米药物可以对内源性和外源性微环境做出特异性反应，有效地将药物递送到特定的靶标,并参与生物成像和小分子检测等活动。纳米在微（NIM）输送系统，如金属，金属氧化物和上转换纳米颗粒(NPs)，量子点,和碳材料，在克服眼球内生理屏障的存在方面显示出一定的优势,并被广泛用于眼科疾病的治疗。很少有研究，然而,已经评估了NIM递送系统治疗眼底新生血管性疾病（FND）的疗效。本研究描述了与使用NIM递送系统治疗FND相关的主要临床治疗策略和不良事件，并总结了必须克服的解剖学障碍。在这次审查中,我们希望强调眼内微环境正常化的原理，旨在为设计新的NIM输送系统以治疗特定FND提供更合理的方法。
