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Abstract：
Despite recent advances in tumor diagnosis and treatment technologies, the number of cancer cases and deaths worldwide continues to increase yearly, creating an urgent need to find new methods to prevent or treat cancer. Sulforaphane (SFN), as a member of the isothiocyanates (ITCs) family, which is the hydrolysis product of glucosinolates (GLs), has been shown to have significant preventive and therapeutic cancer effects in different human cancers. Early studies have shown that SFN scavenges oxygen radicals by increasing cellular defenses against oxidative damage, mainly through the induction of phase II detoxification enzymes by nuclear factor erythroid 2-related factor 2 (Nrf2). More and more studies have shown that the anticancer mechanism of SFN also includes induction of apoptotic pathway in tumor cells, inhibition of cell cycle progression, and suppression of tumor stem cells. Therefore, the application of SFN is expected to be a necessary new approach to treating cancer. In this paper, we review the multiple molecular mechanisms of SFN in cancer prevention and treatment in recent years, which can provide a new vision for cancer treatment.
摘要：
尽管肿瘤诊断和治疗技术最近取得了进展，全球癌症病例和死亡人数逐年增加，迫切需要找到预防或治疗癌症的新方法。萝卜硫素(SFN),作为异硫氰酸酯（ITCs）家族的成员，它是芥子油苷（GL）的水解产物，已被证明在不同的人类癌症中具有显著的预防和治疗癌症效果。早期研究表明，SFN通过增加细胞对氧化损伤的防御能力来清除氧自由基，主要通过核因子类2相关因子2（Nrf2）诱导II期解毒酶。越来越多的研究表明,SFN的抗癌机制还包括诱导肿瘤细胞凋亡通路,抑制细胞周期进程，和抑制肿瘤干细胞。因此,SFN的应用有望成为治疗癌症的必要新途径。在本文中,综述了近年来SFN在肿瘤防治中的多分子机制,这可以为癌症治疗提供新的视野。
