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Abstract：
OBJECTIVE: To evaluate the agreement between quantitative ultrasound system fat fraction (USFF) and proton magnetic resonance spectroscopy (1H-MRS) and the diagnostic value of USFF in assessing metabolic-associated fatty liver disease (MAFLD).
METHODS: The participants with or suspected of MAFLD were prospectively recruited and underwent 1H-MRS, USFF, and controlled attenuation parameter (CAP) measurements. The correlation between USFF and 1H-MRS was assessed using Pearson correlation coefficients. The USFF diagnostic performance for different grades of steatosis was evaluated using receiver operating characteristic curve analysis (ROC) and was compared with CAP, visual hepatic steatosis grade (VHSG).
RESULTS: A total of 113 participants (mean age 44.79 years ± 13.56 (SD); 71 males) were enrolled, of whom 98 (86.73%) had hepatic steatosis (1H-MRS ≥ 5.56%). USFF showed a good correlation (Pearson r = 0.76) with 1H-MRS and showed a linear relationship, which was superior to the correlation between CAP and 1H-MRS (Pearson r = 0.61). The USFF provided high diagnostic performance for different grades of hepatic steatosis, with ROC from 0.84 to 0.98, and the diagnostic performance was better than that of the CAP and the VHSG. The cut-off values of the USFF were different for various grades of steatosis, and the cut-off values for S1, S2, and S3 were 12.01%, 19.98%, and 22.22%, respectively.
CONCLUSIONS: There was a good correlation between USFF and 1H-MRS. Meanwhile, USFF had good diagnostic performance for hepatic steatosis and was superior to CAP and VHSG. USFF represents a superior method for noninvasive quantitative assessment of MAFLD.
UNASSIGNED: Quantitative ultrasound system fat fraction (USFF) accurately assesses liver fat content and has a good correlation with magnetic resonance spectroscopy (1H-MRS) for the assessment of metabolic-associated fatty liver disease (MAFLD), as well as for providing an accurate quantitative assessment of hepatic steatosis.
CONCLUSIONS: Current diagnostic and monitoring modalities for metabolic-associated fatty liver disease have limitations. USFF correlated well with 1H-MRS and was superior to the CAP. USFF has good diagnostic performance for steatosis, superior to CAP and VHSG.
METHODS: The participants with or suspected of MAFLD were prospectively recruited and underwent 1H-MRS, USFF, and controlled attenuation parameter (CAP) measurements. The correlation between USFF and 1H-MRS was assessed using Pearson correlation coefficients. The USFF diagnostic performance for different grades of steatosis was evaluated using receiver operating characteristic curve analysis (ROC) and was compared with CAP, visual hepatic steatosis grade (VHSG).
RESULTS: A total of 113 participants (mean age 44.79 years ± 13.56 (SD); 71 males) were enrolled, of whom 98 (86.73%) had hepatic steatosis (1H-MRS ≥ 5.56%). USFF showed a good correlation (Pearson r = 0.76) with 1H-MRS and showed a linear relationship, which was superior to the correlation between CAP and 1H-MRS (Pearson r = 0.61). The USFF provided high diagnostic performance for different grades of hepatic steatosis, with ROC from 0.84 to 0.98, and the diagnostic performance was better than that of the CAP and the VHSG. The cut-off values of the USFF were different for various grades of steatosis, and the cut-off values for S1, S2, and S3 were 12.01%, 19.98%, and 22.22%, respectively.
CONCLUSIONS: There was a good correlation between USFF and 1H-MRS. Meanwhile, USFF had good diagnostic performance for hepatic steatosis and was superior to CAP and VHSG. USFF represents a superior method for noninvasive quantitative assessment of MAFLD.
UNASSIGNED: Quantitative ultrasound system fat fraction (USFF) accurately assesses liver fat content and has a good correlation with magnetic resonance spectroscopy (1H-MRS) for the assessment of metabolic-associated fatty liver disease (MAFLD), as well as for providing an accurate quantitative assessment of hepatic steatosis.
CONCLUSIONS: Current diagnostic and monitoring modalities for metabolic-associated fatty liver disease have limitations. USFF correlated well with 1H-MRS and was superior to the CAP. USFF has good diagnostic performance for steatosis, superior to CAP and VHSG.
摘要：
目的：评估定量超声系统脂肪分数（USFF）和质子磁共振波谱（1H-MRS）之间的一致性以及USFF在评估代谢相关脂肪性肝病（MAFLD）中的诊断价值。
方法：前瞻性招募患有或怀疑患有MAFLD的参与者，并接受1H-MRS，USFF,和受控衰减参数(CAP)测量。使用Pearson相关系数评估USFF和1H-MRS之间的相关性。使用受试者工作特征曲线分析（ROC）评估不同等级脂肪变性的USFF诊断性能，并与CAP进行比较。视觉肝脏脂肪变性分级（VHSG）。
结果：共有113名参与者（平均年龄44.79岁±13.56（SD）；71名男性）入组，其中98例（86.73%）患有肝脂肪变性（1H-MRS≥5.56%）。USFF与1H-MRS呈良好的相关性(Pearsonr=0.76),呈线性关系,优于CAP与1H-MRS的相关性(Pearsonr=0.61)。USFF为不同级别的肝脂肪变性提供了高诊断性能，ROC为0.84～0.98，诊断性能优于CAP和VHSG。不同等级的脂肪变性的USFF的截断值不同，S1、S2和S3的截止值为12.01%，19.98%,和22.22%，分别。
结论：USFF和1H-MRS之间存在良好的相关性。同时,USFF对肝脂肪变性具有良好的诊断性能，优于CAP和VHSG。USFF代表了一种用于MAFLD的非侵入性定量评估的优越方法。
■定量超声系统脂肪分数（USFF）可准确评估肝脏脂肪含量，并与磁共振波谱（1H-MRS）具有良好的相关性，可评估代谢相关的脂肪肝疾病（MAFLD），以及提供肝脂肪变性的准确定量评估。
结论：目前代谢相关脂肪肝的诊断和监测模式存在局限性。USFF与1H-MRS相关性良好，优于CAP。USFF对脂肪变性具有良好的诊断性能，优于CAP和VHSG。
方法：前瞻性招募患有或怀疑患有MAFLD的参与者，并接受1H-MRS，USFF,和受控衰减参数(CAP)测量。使用Pearson相关系数评估USFF和1H-MRS之间的相关性。使用受试者工作特征曲线分析（ROC）评估不同等级脂肪变性的USFF诊断性能，并与CAP进行比较。视觉肝脏脂肪变性分级（VHSG）。
结果：共有113名参与者（平均年龄44.79岁±13.56（SD）；71名男性）入组，其中98例（86.73%）患有肝脂肪变性（1H-MRS≥5.56%）。USFF与1H-MRS呈良好的相关性(Pearsonr=0.76),呈线性关系,优于CAP与1H-MRS的相关性(Pearsonr=0.61)。USFF为不同级别的肝脂肪变性提供了高诊断性能，ROC为0.84～0.98，诊断性能优于CAP和VHSG。不同等级的脂肪变性的USFF的截断值不同，S1、S2和S3的截止值为12.01%，19.98%,和22.22%，分别。
结论：USFF和1H-MRS之间存在良好的相关性。同时,USFF对肝脂肪变性具有良好的诊断性能，优于CAP和VHSG。USFF代表了一种用于MAFLD的非侵入性定量评估的优越方法。
■定量超声系统脂肪分数（USFF）可准确评估肝脏脂肪含量，并与磁共振波谱（1H-MRS）具有良好的相关性，可评估代谢相关的脂肪肝疾病（MAFLD），以及提供肝脂肪变性的准确定量评估。
结论：目前代谢相关脂肪肝的诊断和监测模式存在局限性。USFF与1H-MRS相关性良好，优于CAP。USFF对脂肪变性具有良好的诊断性能，优于CAP和VHSG。
