Abstract：
For older Caucasian women and men, the QCT (quantitative CT) lumbar spine (LS) bone mineral density (BMD) threshold for classifying osteoporosis is 80 mg/ml. It was recently proposed that, for older East Asian women, the QCT LS BMD value equivalent to the Caucasian women\'s threshold of 80 mg/mL is about 45∼50 mg/ml. For a data of 328 cases of Chinese men (age: 73.6 ± 4.4 years) who had QCT LS BMD and DXA LS BMD at the same time and with the DXA BMD value of ≤ 0.613 g/cm2 to classify osteoporosis, the corresponding QCT LS BMD threshold is 53 mg/ml. Osteoporotic-like vertebral fracture sum score (OLVFss) ≤ -2.5 has been proposed to diagnose osteoporosis. For 316 cases of Chinese men (age:73.7±4.5 years), OLVFss ≤ -2.5 defines an osteoporosis prevalence of 4.4%; to achieve this osteoporosis prevalence, the corresponding QCT LS BMD value is < 47.5 mg/ml. In the China Action on Spine and Hip Status study, a Genant grades 2/3 radiographic \'osteoporotic vertebral fracture\' prevalence was 2.84% for Chinese men (total n = 1267, age: 62.77 ± 9.20 years); to achieve this osteoporosis prevalence, the corresponding BMD value was < 42.5 mg/ml. In a study of 357 Beijing older men, according to the clinical fragility fracture prevalence and femoral neck DXA T-score, the QCT LS BMD value to classify osteoporosis was between 39.45 mg/ml and 51.38 mg/ml. For older Chinese men (≥ 50 years), we recommend the cutpoint for the QCT LS BMD definition of osteoporosis to be 45∼50 mg/ml which is the same as the value for Chinese women.
摘要：
对于年长的白人女性和男性，QCT（定量CT）腰椎（LS）骨密度（BMD）阈值为80mg/ml。最近有人提出，对于年长的东亚女性来说，QCTLSBMD值相当于高加索女性80mg/mL的阈值约为45~50mg/ml。对于328例同时患有QCTLSBMD和DXALSBMD且DXABMD值≤0.613g/cm2的中国男性（年龄：73.6±4.4岁）进行骨质疏松症分类的数据，相应的QCTLSBMD阈值为53mg/ml。已提出骨质疏松样椎骨骨折总和评分（OLVFss）≤-2.5来诊断骨质疏松症。中国男性316例（年龄：73.7±4.5岁），OLVFss≤-2.5定义了4.4%的骨质疏松症患病率；为了达到这种骨质疏松症患病率，相应的QCTLSBMD值<47.5mg/ml。在中国脊柱和髋关节状况研究中，中国男性的2/3级放射学“骨质疏松性椎体骨折”患病率为2.84％（总n=1267，年龄：62.77±9.20岁）；要达到这种骨质疏松症患病率，相应的BMD值<42.5mg/ml。在一项对357名北京老年男性的研究中，根据临床脆性骨折患病率和股骨颈DXAT评分，对骨质疏松症进行分类的QCTLSBMD值在39.45mg/ml至51.38mg/ml之间.对于中国老年男性（≥50岁），我们建议QCTLSBMD对骨质疏松症的定义为45~50mg/ml，与中国女性的值相同。
