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Abstract：
With the increasing application of magnetic compression anastomosis (MCA) in gastrointestinal anastomosis, we identified an interesting phenomenon that an anastomosis is more prone to stenosis after endoscopic gastrointestinal MCA. We hypothesized that the increase in tissue tension during endoscopic procedures is the cause of anastomotic stenosis. In this study, we investigated the effect of tissue tension on gastroduodenal bypass MCA in Sprague-Dawley (SD) rats. Twenty SD rats were divided into the study group (high-tension group, n = 10) and control group (no tension group, n = 10), wherein the rats underwent complete gastroduodenal bypass magnetic anastomosis under high tension and no tension of the digestive tract, respectively. Anastomotic specimens were obtained 4 weeks after the operation, and anastomotic diameters of the two groups were observed and measured. The histological difference was observed by hematoxylin & eosin and Masson staining. The operation was successfully completed in all rats, and all survived until 4 weeks postoperatively. Anastomotic measurements revealed that the anastomosis diameter was significantly smaller in the study group than in the control group, and there were three cases of severe anastomotic stenosis. Histological observation showed that the amount of collagen fibers in the anastomosis was greater in the study group than in the control group. The results suggest that the high-tension state of the digestive tract is an important factor leading to anastomotic stenosis, and thus, we put forward the Yan-Zhang\'s Tissue Tension Theory of MCA to explain this phenomenon.
摘要：
随着磁压缩吻合术(MCA)在胃肠吻合术中的应用越来越多,我们发现了一个有趣的现象，即在内镜下胃肠道MCA后吻合更容易发生狭窄。我们假设内窥镜手术期间组织张力的增加是吻合口狭窄的原因。在这项研究中,我们研究了组织张力对Sprague-Dawley（SD）大鼠胃十二指肠旁路MCA的影响。20只SD大鼠分为研究组(高张力组,n=10）和对照组（无张力组，n=10),其中大鼠在高张力和无消化道张力下进行完全胃十二指肠旁路磁吻合，分别。术后4周获得吻合标本,观察并测量两组吻合口直径。通过苏木精和伊红和Masson染色观察组织学差异。所有大鼠均顺利完成手术,全部存活至术后4周。吻合口测量显示，研究组吻合口直径明显小于对照组，吻合口重度狭窄3例。组织学观察显示，研究组吻合口胶原纤维的数量大于对照组。结果提示消化道高压状态是导致吻合口狭窄的重要因素,因此，我们提出了颜张的MCA组织张力理论来解释这一现象。
