化疗诱导的 IL23A 高表达通过共激活 CTL 的 PI3K - AKT 信号通路增强 TNBC 中抗 PD - 1 治疗的功效。
关键词: Chemotherapy IL-23 Immune checkpoints inhibitor Immunotherapy Triple-negative breast cancer
Mesh : Humans Proto-Oncogene Proteins c-akt / metabolism Triple Negative Breast Neoplasms / drug therapy metabolism immunology Signal Transduction / drug effects Phosphatidylinositol 3-Kinases / metabolism Programmed Cell Death 1 Receptor / metabolism Cell Line, Tumor Female T-Lymphocytes, Cytotoxic / drug effects immunology metabolism Interleukin-23 Subunit p19 / metabolism Animals Mice Antibodies, Monoclonal / pharmacology
来 源:
DOI:10.1038/s41598-024-65129-7
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