PDF(Pubmed)
Abstract：
Breast cancer, as the most common cancer, has surpassed lung cancer worldwide. The neutrophil-to-lymphocyte ratio (NLR) has been linked to the onset of cancer and its prognosis in recent studies. However, quite a few studies have shown that there is a link between NLR and lymph node metastases in cN0 hormone receptor-positive (HR(+)) breast cancer. The purpose of this study was to evaluate the correlation between NLR and lymph node metastases in cN0 HR(+) breast cancer patients. From January 2012 to January 2022, 220 patients with cN0 HR(+) invasive breast cancers were enrolled in this study. The relationship between NLR and pathological data was statistically examined. The receiver operating characteristic (ROC) curve was used to determine the optimal cutoff of NLR, a chi-squared test was used for the univariate analysis, and logistic analysis was used for the multivariate analysis. The NLR had an optimal cutoff of 2.4 when the Jorden index was at a maximum. Patients with axillary lymph node metastases had a higher NLR (P < 0.05). A Univariate analysis showed that there were significant differences in cN0 HR(+) breast cancer with axillary lymph node metastasis among different clinical stages, histological grades, Ki-67 levels, tumor sizes, and NLR levels (P < 0.05). Clinical stage, tumor size, and NLR were found to be independent risk factors for lymph node metastases in multifactorial analysis. In cN0 HR(+) breast cancer, NLR is an independent risk factor for lymph node metastases. An NLR ≥ 2.4 indicates an increased probability of lymph node metastases. An elevated preoperative NLR has a high predictive value for axillary lymph node metastases.
摘要：
乳腺癌,作为最常见的癌症，已经超过了全世界的肺癌。在最近的研究中，中性粒细胞与淋巴细胞的比率（NLR）与癌症的发作及其预后有关。然而,相当多的研究表明,在cN0激素受体阳性(HR(+))乳腺癌中,NLR与淋巴结转移之间存在联系.目的评价cN0HR(+)乳腺癌患者NLR与淋巴结转移的相关性。2012年1月至2022年1月，共纳入220例cN0HR(+)浸润性乳腺癌患者。统计NLR与病理资料的关系。受试者工作特性(ROC)曲线用于确定NLR的最佳截止值,单变量分析使用卡方检验，多变量分析采用logistic分析。当乔登指数最大时，NLR的最佳截止值为2.4。腋窝淋巴结转移患者NLR较高(P<0.05)。单因素分析显示cN0HR(+)乳腺癌腋窝淋巴结转移在不同临床分期之间存在显著差异,组织学分级,Ki-67级别,肿瘤大小,NLR水平(P<0.05)。临床分期,肿瘤大小,在多因素分析中发现NLR是淋巴结转移的独立危险因素。在cN0HR（+）乳腺癌中，NLR是淋巴结转移的独立危险因素。NLR≥2.4表明淋巴结转移的可能性增加。术前NLR升高对腋窝淋巴结转移有较高的预测价值。
