关键词: AIDS Cohort study HIV Selection bias Study design

来  源:   DOI:10.4178/epih.e2024055

Abstract:
UNASSIGNED: The Korea HIV/AIDS Cohort Study has been conducted prospectively for 18 years. However, it faces limitations in representing the entire population of patients with HIV in Korea. To address these limitations and validate the study design, we analyzed characteristics across several HIV datasets.
UNASSIGNED: We compared epidemiological and clinical characteristics from 3 datasets: the Korea HIV/AIDS Cohort Study (dataset 1, n=1,562), retrospective cohort data (dataset 2, n=2,665), and the national HIV reporting system of the Korea Disease Control and Prevention Agency (KDCA) (dataset 3, n=17,403).
UNASSIGNED: The demographic characteristics of age, sex, and age at HIV diagnosis did not differ significantly across datasets. However, dataset 3 contained a higher percentage of patients diagnosed after 2008 (69.5%) than the other datasets. Regarding transmission routes, same-sex contact accounted for a greater proportion of dataset 1 (59.8%) compared to datasets 2 (20.9%) and 3 (32.6%). The percentage of patients with CD4 T-cell counts below 200/mm3 at HIV diagnosis was higher in datasets 1 (39.4%) and 2 (33.3%) compared to dataset 3 (16.3%). Initial HIV viral load measurements were not obtained for dataset 3.
UNASSIGNED: The Korea HIV/AIDS Cohort Study demonstrated representativeness regarding the demographic characteristics of Korean patients. Of the sources, dataset 1 contained the most data on transmission routes. While the KDCA data encompassed all HIV patients, it lacked detailed clinical information. To improve the representativeness of the Korea HIV/AIDS Cohort Study, we propose expanding and revising the cohort design and enrolling more patients who have been recently diagnosed.
摘要:
韩国艾滋病毒/艾滋病队列研究已经进行了18年。然而,它在代表韩国艾滋病毒患者的整个人口方面面临着局限性。为了解决这些限制并验证研究设计,我们分析了几个HIV数据集的特征.
我们比较了3个数据集的流行病学和临床特征:韩国HIV/AIDS队列研究(数据集1,n=1,562),回顾性队列数据(数据集2,n=2,665),和韩国疾病控制和预防局(KDCA)的国家艾滋病毒报告系统(数据集3,n=17,403)。
年龄的人口统计特征,性别,和HIV诊断年龄在数据集之间没有显著差异.然而,数据集3包含比其他数据集更高的2008年后诊断的患者百分比(69.5%)。关于传输路线,与数据集2(20.9%)和数据集3(32.6%)相比,同性接触在数据集1中所占的比例更高(59.8%).与数据集3(16.3%)相比,在HIV诊断中CD4T细胞计数低于200/mm3的患者百分比在数据集1(39.4%)和2(33.3%)中更高。对于数据集3,未获得初始HIV病毒载量测量。
韩国HIV/AIDS队列研究显示了关于韩国患者的人口统计学特征的代表性。在来源中,数据集1包含最多传输路由数据。虽然KDCA数据涵盖了所有HIV患者,它缺乏详细的临床信息。为了提高韩国艾滋病毒/艾滋病队列研究的代表性,我们建议扩大和修改队列设计,并招募更多最近确诊的患者.
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