Abstract：
Clerodendranthus spicatus (Thunb.) C.Y.Wu (CS) is a widely studied plant that shows potential in treating urinary diseases. Previous studies have focused on its chemical composition, pharmacological effects, and clinical applications. This review aims to provide a comprehensive summary and evaluation of the existing literature on CS. It also suggests future research directions to increase our understanding of its medicinal value. 129 pieces of literature were selected from several databases, including PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wan-fang Database, and Google Scholar, and were analyzed. Forty-five active compounds of CS have pharmacological effects such as lowering uric acid, anti-inflammation, anti-oxidation, and kidney protection. The potential mechanisms of these effects may be related to inhibiting transforming growth factor β1 (TGF-β1) activation, reducing inflammatory factors such as IL-8, IL-1β, TNF-α, PGE2, IFN-γ, and IL-6 levels, suppressing the activation of NF-κB, JAK/STAT pathway, enhancing the clearance of ROS, MDA DPPH·, and O2 ̇ -, and regulating the expression of apoptosis-related pathways and proteins. This paper also discusses the quality control of CS and its efficacy and safety in treating urinary diseases. The study concludes that CS has a high potential for treating urinary diseases. Future studies should focus on observing the metabolic changes of CS active compounds in vivo and investigating the effects of CS on key signaling pathways. Additionally, more standardized and reasonable clinical studies and safety evaluation experiments should be conducted to obtain more clinical data.
摘要：
Clerodendranthusspicatus(Thunb.）C.Y.Wu（CS）是一种被广泛研究的植物，显示出治疗泌尿系疾病的潜力。以前的研究集中在它的化学成分上，药理作用，和临床应用。这篇综述旨在对现有的CS文献进行全面的总结和评价。它还提出了未来的研究方向，以增加我们对其药用价值的理解。从几个数据库中选择了129篇文献，包括PubMed,WebofScience,中国国家知识基础设施(CNKI),万方数据库,和谷歌学者，并进行了分析。CS的45种活性化合物具有降低尿酸等药理作用，抗炎，抗氧化，和肾脏保护。这些作用的潜在机制可能与抑制转化生长因子β1（TGF-β1）的激活有关。减少炎症因子，如IL-8，IL-1β，TNF-α,PGE2,IFN-γ,和IL-6水平，抑制NF-κB的激活，JAK/STAT通路,增强ROS的清除，MDADPPH·，和O2--，调节凋亡相关通路和蛋白的表达。本文还讨论了CS的质量控制及其治疗泌尿系疾病的有效性和安全性。该研究得出结论，CS具有很高的治疗泌尿系疾病的潜力。未来的研究应集中在观察CS活性化合物在体内的代谢变化以及研究CS对关键信号通路的影响。此外,应进行更加规范合理的临床研究和安全性评价实验,以获得更多的临床数据。
