Abstract：
OBJECTIVE: To evaluate ophthalmological, neurological, radiological, and laboratory data in patients with multiple sclerosis (MS) and to identify new ophthalmological factors that could be helpful as biomarkers of the disease, potentially leading to an earlier prediction of disease course and disability progression.
METHODS: Retrospective, cross-sectional-study.
METHODS: Best-corrected visual acuity (BCVA), ophthalmological biomicroscopy of the anterior segment and fundus, structural optical coherence tomography (OCT) with retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC), and OCT angiography (OCTA) with vascular density (VD) were performed. The following clinical and neuro-radiological features were assessed: MS phenotype, disease duration, clinical severity, type of treatment, and T2-weighted lesion and T1-weighted Gd+ enhancing lesion number on the brain and spinal cord MRI.
RESULTS: One hundred and six patients (212 eyes) were analyzed. Sixty-six of them (62.2%) had MS and 40 (37.8%) were matched healthy controls (HCs). patients with MS showed lower RNFL, GCC, and VD in the radial peripapillary capillary plexus than controls in both eyes (P < .05). By Performing a logistic regression with a distinct MS outcome for both eyes, we were able to demonstrate that the value that was most predictive of MS was the average GCC thickness (P = .009). Regression analysis demonstrated that patients with a higher T2-weighted lesions showed a lower RNFL thickness value and reduced GCC and VD values than those with a low lesion load (P < .01 and P < .05, respectively). Similarly, relapsing MS patients showed lower RNFL values (P < .05).
CONCLUSIONS: Several OCT and OCTA-optic nerve parameters could be useful prognostic biomarkers for the MS disease course in clinical practice. However, it is necessary to do additional research with larger sample sizes in order to validate these findings.
METHODS: Retrospective, cross-sectional-study.
METHODS: Best-corrected visual acuity (BCVA), ophthalmological biomicroscopy of the anterior segment and fundus, structural optical coherence tomography (OCT) with retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC), and OCT angiography (OCTA) with vascular density (VD) were performed. The following clinical and neuro-radiological features were assessed: MS phenotype, disease duration, clinical severity, type of treatment, and T2-weighted lesion and T1-weighted Gd+ enhancing lesion number on the brain and spinal cord MRI.
RESULTS: One hundred and six patients (212 eyes) were analyzed. Sixty-six of them (62.2%) had MS and 40 (37.8%) were matched healthy controls (HCs). patients with MS showed lower RNFL, GCC, and VD in the radial peripapillary capillary plexus than controls in both eyes (P < .05). By Performing a logistic regression with a distinct MS outcome for both eyes, we were able to demonstrate that the value that was most predictive of MS was the average GCC thickness (P = .009). Regression analysis demonstrated that patients with a higher T2-weighted lesions showed a lower RNFL thickness value and reduced GCC and VD values than those with a low lesion load (P < .01 and P < .05, respectively). Similarly, relapsing MS patients showed lower RNFL values (P < .05).
CONCLUSIONS: Several OCT and OCTA-optic nerve parameters could be useful prognostic biomarkers for the MS disease course in clinical practice. However, it is necessary to do additional research with larger sample sizes in order to validate these findings.
摘要：
目的：评估眼科，神经学,放射学,和多发性硬化症（MS）患者的实验室数据，并确定可能作为该疾病生物标志物的新眼科因素，可能导致疾病进程和残疾进展的早期预测。
方法：回顾性，横断面研究。
方法：最佳矫正视力（BCVA），眼前节和眼底的眼科生物显微镜，结构光学相干断层扫描（OCT）与视网膜神经纤维层（RNFL）和神经节细胞复合体（GCC），行OCT血管造影(OCTA)血管密度(VD)。评估了以下临床和神经放射学特征：MS表型，疾病持续时间,临床严重程度，治疗类型,最后一次脑和脊髓MRI上的T2加权病变负荷加上T1加权Gd增强病变数。
结果：分析了106例患者（212只眼）。其中66例（62.2％）患有MS，40例（37.8％）为匹配的健康对照（HCs）。MS患者表现出更低的RNFL，GCC,放射状乳头周围毛细血管丛的VD比对照组双眼（p<0.05）。通过对双眼进行具有不同MS结果的逻辑回归，我们能够证明MS最具预测性的值是平均GCC厚度(p=0.009).回归分析表明，与具有低病变负荷的患者相比，具有较高T2加权病变的患者显示较低的RNFL厚度值和降低的GCC和VD值（分别为p<0.01和p<0.05）。同样，复发MS患者显示更低的RNFL值(p<0.05)。
结论：在临床实践中，一些OCT和OCTA视神经参数可能是MS病程的有用的预后生物标志物。然而,为了验证这些发现，有必要进行更大样本量的额外研究。
方法：回顾性，横断面研究。
方法：最佳矫正视力（BCVA），眼前节和眼底的眼科生物显微镜，结构光学相干断层扫描（OCT）与视网膜神经纤维层（RNFL）和神经节细胞复合体（GCC），行OCT血管造影(OCTA)血管密度(VD)。评估了以下临床和神经放射学特征：MS表型，疾病持续时间,临床严重程度，治疗类型,最后一次脑和脊髓MRI上的T2加权病变负荷加上T1加权Gd增强病变数。
结果：分析了106例患者（212只眼）。其中66例（62.2％）患有MS，40例（37.8％）为匹配的健康对照（HCs）。MS患者表现出更低的RNFL，GCC,放射状乳头周围毛细血管丛的VD比对照组双眼（p<0.05）。通过对双眼进行具有不同MS结果的逻辑回归，我们能够证明MS最具预测性的值是平均GCC厚度(p=0.009).回归分析表明，与具有低病变负荷的患者相比，具有较高T2加权病变的患者显示较低的RNFL厚度值和降低的GCC和VD值（分别为p<0.01和p<0.05）。同样，复发MS患者显示更低的RNFL值(p<0.05)。
结论：在临床实践中，一些OCT和OCTA视神经参数可能是MS病程的有用的预后生物标志物。然而,为了验证这些发现，有必要进行更大样本量的额外研究。
