FOXK2 扩增促进乳腺癌发展和化疗耐药。
关键词: Breast cancer FOXK2 Gene amplification Oncogene Transcription factor
Mesh : Animals Female Humans Mice 3-Phosphoinositide-Dependent Protein Kinases / metabolism genetics Antineoplastic Agents / pharmacology Breast Neoplasms / genetics pathology drug therapy metabolism Cell Movement / drug effects Cell Proliferation / drug effects Cyclin-Dependent Kinase 2 / genetics metabolism Drug Resistance, Neoplasm / genetics Estrogen Receptor alpha / genetics metabolism Forkhead Transcription Factors / genetics metabolism Gene Amplification Gene Expression Regulation, Neoplastic / drug effects MCF-7 Cells Mice, Nude Pyruvate Dehydrogenase Acetyl-Transferring Kinase / genetics metabolism Thiazoles / pharmacology Xenograft Model Antitumor Assays
来 源:
DOI:10.1016/j.canlet.2024.217074
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